MOLECULAR BASIS FOR AGING AND RADIATION INJURY

The Mueller lab focuses attention on the shared molecular basis for aging and radiation injury. We specifically investigate the roles of microRNAs (miRNA) as tissue-specific mediators serving in the epigenetic control mechanisms that mitigate pathology and support normal tissue repair. We are conducting high throughput miRNA profiling of the Framingham Heart Study Cohort, matching miRNA signatures with the progression of cardiovascular disease and other age-related clinical phenotypes. In a similar fashion the lab collaborates with investigators of the Armed Forces Radiobiological Research Institute to investigate miRNA responses the acute radiation syndrome in laboratory animals. The ultimate goal for these investigations is to identify common mechanism that support the maintenance of tissue normal function and effective repair. Understanding the role of miRNAs in these processes will guide their use as therapeutic tools in the promotion of health.

 

Resources

Publication List
Dr. Mueller Bio
USU Office of Research

 

 

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ongoing research projects

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partners in the last five years

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student publications in the last 5 years

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faculty publications in 10 different journals in the last 5 years