Veterans with post-traumatic stress disorder (PTSD) may persistently re-experience of a traumatic event and require treatment tailored to the unique nature of combat, military culture. A special challenge to mitigate stress-induced anxiety disorder with pharmacological intervention and promoting resilience of symptoms of PTSD are the main research commitment.
Elevated startle response and hyperarousal are hallmarks of PTSD and are generally considered to evince fear (DSM V). To further examine the long lasting efficacy of corticosterone in treating hyperarousal and elevated fear, our present study utilized a learned helplessness stress model in which rats are restrained and subjected to tail shock for three days. These stressed rats develop a delayed long-lasting exaggeration of the acoustic startle response (ASR) and retarded body weight growth, similar to symptoms of PTSD patients.