NEUROBIOLOGY OF TRAUMATIC BRAIN INJURY
Pilot studies in the Agoston Lab indicate that a) repeated exposures to military occupational blast associated with heavy weapons training causes dynamically changing and lasting increases in serum biomarker levels; b) training associated increase in UCH-L1 and GFAP levels indicate ongoing neuronal and glia damage, that can be detected even at the 3 month time point; c) Instructors appear to be specifically affected by repeated exposures as reflected in their higher serum levels of neuron and glia damage markers that may indicate a more chronic disease mechanism. These findings, if verified will provide the basis for developing new safety standards for military occupational blast training.
These and other findings from this laboratory were presented at The 3d Japan-US Technical Information Exchange Forum on Blast Injury (JUFBI 2018), Tokyo, Japan and at the 2018 Military Health System Research Symposium (MHSRS), Kissimmee, Florida U.S. The laboratory’s principal investigator was invited as subject expert at the Department of Defense State of the Science (SoS) meeting on blood-based biomarkers in November 2018 in Ft. Detrick, MD and International Forum on Blast Induced Traumatic Brain injury in Arlington, VA in May 2019.