What We Do

The Pollard Lab focusses on genetic and pharmacologic regulation of inflammation in the lung. Specific applications include cystic fibrosis (CF), where proinflammatory pathology is due to mutations in the CFTR gene, and chronic obstructive pulmonary disease (COPD), which is due to cigarette smoke. A curious parallel between CF and COPD is that exposure to cigarette smoke causes reduction in expression of the CFTR gene. Thus, these two diseases, one genetic and the other acquired, have very similar clinical presentations. In addition, both are risk factors for cancer since CFTR can function as a tumor suppressor gene. Methods for analysis include proinflammatory pathway analysis, next generation RNA-Seq to measure mRNAs and Whole Genome Sequencing (WGS). The focus of our research is to develop novel candidate drugs to block the inflammatory processes in these lung diseases.

 

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Publication List
Dr. Pollard Bio
USU Office of Research