Infectious Diseases and Immunology

Dr. Pratt’s laboratory employs a multidisciplinary approach to studies at the interface between blood coagulation, inflammation and immunology. Early work consisted of molecular modeling and x-ray crystallographic studies, including high-resolution crystal structures that elucidated the mechanism of fibrin polymerization.

In 2020, our laboratory pivoted in response to the COVID-19 pandemic. Current studies include profiling of plasma, serum and cellular fractions from hospitalized COVID-19 patients, focusing particularly on biomarkers and mechanisms of immunothrombosis. Additional collaborative studies of “long-covid” patient samples will launch in 2023.