MEDSCHOOL, MED, Research, Translational Medicine Unit (TMU) - Facilities

LABORATORY CAPABILITIES

Core Analytical & Detection Platforms

• UHPLC-MS/MS: Targeted quantitative analysis, trace-level detection of parent compounds and metabolites, ADME studies, and quantification of biomarkers, hormones, drugs, peptides, and oligonucleotides
• HPLC-UV & HPLC-FLD: Quantification/characterization of pharmaceutical impurities, naturally fluorescent or fluorescently tagged compounds, and pharmacokinetic/pharmacodynamic support
• GC/MS: Detection and quantification of volatile, thermally stable molecules and metabolic products in biological matrices
• Microplate-based assays: Absorbance, ELISA antibody quantification, enzyme kinetics, and cell-based functional assays

Pharmacokinetic and Pharmacodynamic Research

• ADME, bioavailablility, bioequivalence, dose-proportionality, drug interaction, and special population studies
• Advanced PK/P modeling and parameter analysis via Phoenix WinNonlin

Metabolomics & Biomarker Profiling

• Disease-state profiling (cardiovascular disease, POTS, renal disease, oncology, and post-infectious syndromes)
• Specialized clearance assays (iothalamate GFR evaluation, inulin clearance) and targeted metabolite panels

Translational Cellular Models & Processing

• Primary blood fractionation and PBMC isolation
• Transfection, cell harvesting/homogenization, and cytotoxicity assays (LDH)
• Model systems: HEK 293 cells, hiPSCs, and hiPSC-derived cardiomyocytes