Mark Haigney MD

Education

BA: University of Virginia, Charlottesville, VA
MD: Vanderbilt University School of Medicine, Nashville, TN
Post-doctoral training: Johns Hopkins Hospital, Baltimore, MD

Biography

Dr. Haigney is a board-certified cardiologist and electrophysiologist who attends in the Walter Reed Cardiology and Genetic Cardiology clinics. The Cardiovascular Laboratory is primarily concerned with identifying mechanisms of sudden cardiac death, including those related to genetically transmitted arrhythmia syndromes. The lab combines basic and clinical investigations in a translational approach. A tachycardia-pacing model of large animal heart failure has been in place for ten years and has allowed evaluation of specific ion channels and their alteration by heart failure. The clinical research component has evaluated a number of approaches to prediction of arrhythmic
events, with particular emphasis on unstable repolarization as manifest by QT interval variability. The laboratory has investigated the use of inducible pluripotent stem cell derived myocytes to understand the mechanisms of cardiac arrest in human subjects. Dr. Haigney is the Director of the Defense Health Agency-funded Military Cardiovascular Outcomes Research (MiCOR) program. The MiCOR research portfolio includes 12 clinical research projects intended to understand the impact of military service- particularly inherited syndromes, stress, weight-gain, exercise, COVID-19 infection, and pharmacotherapy- on cardiovascular risk.

Representative publications, projects, and/or deployments

2013 Carol Johns Medal for Service, Uniformed Services University

2016 Civilian Educator of the Year, School of Medicine, Uniformed Services University

2014- 2018 Treasurer, International Society for Holter and Noninvasive Electrocardiology

2015-6 Chair, National American Heart Association Cardiac Electrophysiology- Clinical Peer Review Study Group,

2013--9 American College of Cardiology, National Cardiovascular Data Registry on Implantable Defibrillator, Research and Publication Committee

DSMB Member MADIT RIT, MADT CHIC, JAVA CRT, WR1877, WR1849

2021 President-elect, International Society for Holter and Noninvasive Electrocardiography

Bibliography

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. Methadone Destabilizes Cardiac Repolarization during Sleep. Clinical Pharmacology & Therapeutics. 2021 Jul 19. doi: 10.1002/cpt.2368. PMID: 34287835

Krantz MJ, Palmer RB, Haigney MC. Cardiovascular Complications of Opioid Use: JACC State-of- the-Art Review. J Am Coll Cardiol. 2021 Jan 19;77(2):205-223. doi:10.1016/j.jacc.2020.11.002. PMID: 33446314

Magee C, Haigney MC. Cardiovascular Screening in the US Military: Time to Reconsider the Electrocardiogram. Mil Med. 2020 Feb 17. pii: usaa002. doi: 10.1093/milmed/usaa002. PMID: 32065233

Geiger R, Klein MG, Fatima N, Krantz M, Haigney MC, Flagg T. Rapid Assessment of Proarrhythmic Potential using Human iPSC-Derived Cardiomyocytes. JACC Clin Electrophysiol. 2020;6(14):1860- 1862. doi: 10.1016/j.jacep.2020.08.034. PMID: 33357585

Nazari MA, Rosenblum JS, Haigney MC, Rosing DR, Pacak K. Current Views: Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma. J Am Coll Cardiol. 2020 Jul 28;76(4):451-464. doi: 10.1016/j.jacc.2020.04.080. PMID: 32703516

Zareba W, Daubert JP, Beck CA, Huang DT, Alexis JD, Brown MW, Pyykkonen K, McNitt S, Oakes D, Feng C, Aktas MK, Ayala-Parades F, Baranchuk A, Dubuc M, Haigney M, Mazur A, McPherson CA, Mitchell LB, Natale A, Piccini JP, Raitt M, Rashtian MY, Schuger C, Winters S, Worley SJ, Ziv O, Moss AJ; RAID Trial Investigators. Ranolazine in High-Risk Patients With Implanted Cardioverter- Defibrillators: The RAID Trial. JACC 2018 72(6):636-645

Klein MG, Shou M, Stohlman J, Solhjoo S, Haigney M, Tidwell RR, Goldstein RE, Flagg TP, Haigney MC. Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart. Heart Rhythm. 2017. PMID: 28396172

Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G. Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem Cells Transl Med. 2017 Feb;6(2):527-538. PMID: 28191759

Fatima N, Devin C. Cohen, Gauthaman Sukumar, Tristan M. Sissung, James F. Schooley, Jr., Mark C. Haigney, William C. Claycomb, Rachel T. Cox, Clifton L. Dalgard, Susan E. Bates, and Thomas P. Flagg. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis. Frontiers in Pharmacology 2015 6 1-9.

Klein MG, Haigney MCP, Mehler PS, Fatima N, Flagg TP, Krantz MJ. Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide. JACC Clin Electrophysiol. 2016;2(7):784-789