Ying-Hong Feng

M.D., Ph.D

Department of Primary Appointment:
School of Medicine
Pharmacology & Molecular Therapeutics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Receptor structure-function & signaling; Epigenome editing & transcription regulation
Translational research in neurodegenerative diseases, mood disorder, cancer, diabetes, and cardiovascular diseases
Office Phone


1978-1983, M.D., Wuhan University School of Medicine, Wuhan, China
1990-1994, Ph.D., Biochemistry, University of Oxford, Oxford, UK
1994-1997, Postdoctoral, Molecular Cardiology, Cleveland Clinic Foundation


Feng’s lab has three research programs. The first is about crosstalk signaling of receptors in the form of receptor dimerization in pathophysiology such as vascular inflammation, metabolism (type 2 diabetes), pain (silent myocardial ischemia), depression, immunosuppression, cancer progression, and etc. The second is about translational research on neurodegenerative diseases and cancer with focus on novel splicing variants, of critical genes that are known to play an important role in depression, neurodegeneration, neuroregeneration, exosome biology, tumorigenesis, and cancer progression. The last is to develop novel technologies for genome editing and epigenome editing.

Representative publications, projects, and/or deployments

Feng YH, Li X, Zeng R, Gorodeski GI. Endogenously Expressed Truncated P2X7 Receptor Lacking the C-Terminus is Preferentially Upregulated in Epithelial Cancer Cells and Fails to Mediate Ligand-Induced Pore Formation and Apoptosis. Nucleosides Nucleotides Nucleic Acids. 25:1271-6 (2006)

Feng YH, Li X, Zeng R, Gorodeski GI. Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore formation and apoptosis. Nucleosides Nucleotides Nucleic Acids. 25(9-11):1271-6 (2006)

Chen M, Wang T, Liao ZX, Pan XL, Feng YH, Wang H. Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat. Exp Toxicol Pathol. 59: 245-51 (2007)

30. Zhang X, Wang G, Dupre DJ, Feng Y, Robitaille M, Lazartigues E, Feng YH, Hebert TE, Wu G. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. J Pharmacol Exp Ther. 330(1):109-17 (2009)

31. Guo J, Li ZC and Feng YH. Expression and activation of the reprogramming transcription factors. Biochem Biophys Res Commun. 390(4):1081-6 (2009)

32. Zhang J, Villacorta L, Chang L, Fan Z, Hamblin M, Zhu T, Chen CS, Cole MP, Schopfer FJ, Deng CX, Garcia-Barrio MT, Feng YH, Freeman BA, Chen YE. Nitrated oleic acid inhibits Angiotensin II-induced hypertension. Circ Res, 107(4):540-8 (2010)

34. Day RD, Lee YH, Han L, Kim YC, Feng YH. Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms. Am J Physiol Lung Cell Mol Physiol, 301(5):L772-81 (2011)

35. Wang TT, Chen M, Liu L, Cheng H, Yan YE, Feng YH*, Wang H. Nicotine induces a single CpG methylation in the StAR promoter: a potential mechanism for reduced StAR expression and cortisol production. Toxicol and Applied Pharmacol. 257(3):328-37 (2011) *Co-senior author

37. Wang H, Yin H, Yan F, Sun M, Du L, Peng W, Li Q, Feng Y, Zhou Y. Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance. Oncotarget. 6(5):2827-42 (2015).

38. Li K, Pang J, Cheng H, Wei-Peng Liu WP, Chen MK, Yun Luo Y, Di JM, Zhang H, Huang WT, Li LY, Shao CK, Feng YH*, Gao X. Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase. Oncotarget. 6(12):10030-44 (2015) *Co-senior author


Feng YH, Saad Y and Karnik SS. Reversible Inactivation of AT2 Angiotensin II Receptor from Cysteine-Disulfide Bond Exchange. FEBS Letters 484, 133-138 (2000)

Feng YH, Sun Y, and Douglas JG. G??-Independent Constitutive Association of Gs? with SHP-1 and Angiotensin II Receptor AT2 Is Essential in AT2-mediated Activation of SHP-1. Proc. Natl. Acad. Sci. USA 99:12049-12054 (2002)

Wang Q, Li X, Wang L, Feng YH, Zeng R, Gorodeski GI. Anti-apoptotic effects of estrogen in normal and in cancer human cervical epithelial cells. Endocrinology 145:5568-79 (2004)

Wang Q, Wang L, Feng YH, Li X, Zeng R, Gorodeski GI. P2X7-receptor-mediated apoptosis of human cervical epithelial cells. Am J Physiol Cell Physiol. 287:C1349-58 (2004)

Wang L, Feng YH, Gorodeski GI. EGF facilitates epinephrine inhibition of P2X7-receptor pore formation by modulating 2-adrenoceptor internalization and recycling: a signaling network. Endocrinology 146:164-74 (2005)

Feng YH, Zhou LY, Sun Y, and Douglas JG. Functional Diversity of AT2 Receptor Orthologues in Closely related Eutherian. Kidney Intl 67:1731-8 (2005)

eng YH, Wang L, Wang Q, Li X, Zeng R, Gorodeski GI. ATP ligation stimulates GRK-3 - mediated phosphorylation and -arrestin-2- and dynamin-dependent internalization of the P2X7-receptor. Am J Physiol Cell Physiol. 288:C1342-56 (2005)

Feng YH, Zhou L, Qiu R, and Robin Zeng. Single mutations at Asn295 and Leu305 in the cytoplasmic half of TM7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments - A PSEUDO-CONSTITUTIVE ACTIVITY. Mol Pharmacol 68:347-55 (2005)

Feng YH, Ding Y, Ren S, Xu C, Karnik SS. Unconventional homologous internalization of the AT1 receptor induced by G protein-independent signals. Hypertension 46:419-25 (2005)

Feng YH, Li X, Wang L, Zhou L, Gorodeski GI. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem. 281:17228-37 (2006)