Nicholas Bateman PhD

Education

BS in Biological Sciences. SUNY at Buffalo. Buffalo, NY (1997-2002)
PhD in Molecular Pharmacology. University of Pittsburgh School of Medicine. Pittsburgh, PA (2006-2010)
Postdoctoral Fellowship in Cell Biology and Molecular Physiology. University of Pittsburgh School of Medicine. Pittsburgh, PA (2010-2012)

Biography

I am currently the Associate Director of the Gynecologic Cancer Center of Excellence and an Assistant Professor in the Department of Gynecologic Surgery and Obstetrics at Uniformed Services University of the Health Sciences. My training has been focused on basic cell and molecular cancer research as well as application and development of analytical mass spectrometry-based proteomics and bioinformatic approaches to support multi-omic analyses of human tissues and proximal biofluids. I have applied this training throughout my scientific career to basic, translational, and clinical research investigations focused on defining relationships between the human proteome, genome and disease. My current research is focused on refining sample preparation and informatics strategies to support multi-omic analyses of human tissues that leverages cutting-edge histopathologic techniques such as laser microdissection microscopy with an emphasis on defining molecular drivers underlying disease etiology and progression, multidrug resistance and racial disparities in gynecologic malignancies. My personal scientific goal is to leverage high-throughput proteomics and orthogonal multi-omic approaches to define mechanistic biology that is central to disease pathogenesis and translate these findings to the clinic as refined diagnostic methods and therapeutic approaches that will empower personalized medicine and improve the clinical management of cancer and human disease as a whole.

Representative Bibliography

Burdett N, White N, Alsop K, Hunt A, Pandey A, Hamilton P, Abulez T, Liu X, Hoang T, Craig S, Fereday S, Hendley J, Garsed D, Milne K, Kalaria S, Marshall A, Hood B, Wilson K, Conrads K, Pishas K, Ananda S, Scott C, Antill Y, McNally O, Mileshkin L, Hamilton A, Au-Yeung G, Devereux L, Thorne H, Bild A, Bateman NW, Maxwell GL, Chang J, Conrads TP, Nelson B, Bowtell DL. The molecular landscape of homologous recombination deficient, end-stage, high grade serous ovarian cancer. Nat Genet. 2022 Dec;54(12):18

Wong KK, Bateman NW, Ng CW, Tsang YTM, Sun CS, Celestino J, Nguyen TV, Malpica A, Hillman RT, Zhang J, Futreal PA, Rojas C, Conrads KA, Hood BL, Dalgard CL, Wilkerson MD, Phippen NT, Conrads TP, Maxwell GL, Sood AK, Gershenson DM. Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors. J Transl Med. 2022 Dec 17;20(1):606. doi: 10.1186/s12967-022-03820-x.

Garsed DW, Pandey A, Fereday S, Kennedy CJ, Takahashi K, Alsop K, Hamilton P, Hendley J, Chiew YE, Traficante N, Provan P, Ariyaratne D, Au-Yeung G, Bateman NW, Bowes L, Brand A....The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer. Nat Genet. 2022 Dec;54(12):1853-1864. doi: 10.1038/s41588-022-01230-9. Epub 2022 Dec 1. PMID: 36456881

Soltis AR, Bateman NW, Liu J, Nguyen T, Franks TJ, Zhang X, Dalgard CL, Violet C, Somiari S, Yan C, Zeman K, Skinner WJ, Lee JSH, Pollard HB, Turner C, Petricoin EF, Meerzaman D, Conrads TP, Hu H, Shriver CD, Moskaluk CA, Browing RF, Wilkerson MD. Proteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants and therapeutically-relevant pathways. Cell Rep Med. 2022 Nov 15;3(11):100819. doi: 10.1016/j.xcrm.2022.100819.

Penick ER, Bateman NW, Rojas C, Magana C, Conrads K, Zhou M, Hood BL, Wang G, Parikh N, Huang Y, Darcy KM, Casablanca Y, Mhawech-Fauceglia P, Conrads TP, Maxwell GL. Proteomic Alterations Associated with Residual Disease in Neoadjuvant Chemotherapy Treated Ovarian Cancer Tissues. Clin Proteomics. 2022 Oct 4;19(1):35. doi: 10.1186/s12014-022-09372-y. PMID: 36195845

Xuan Y, Bateman NW, Gallien S, Goetze S, Zhou Y, Navarro P, Hu M, Parikh N, Hood BL, Conrads KA, Loosse C, Kitata RB, Piersma SR, Chiasserini D, Zhu H, Hou G, Tahir M, Macklin A, Khoo1 A, Sun A, Crossett B, Sickmann A, Chen YJ, Jimenez CR, Zhou H, Liu S, Larsen MR, Kislinger T, Chen Z, Parker BL, Cordwell SJ, Wollscheid B, Conrads TP. Standardization and Harmonization of Distributed Multi-National Proteotype Analysis supporting Precision Medicine Studies. Nat Commun. 2020 Oct 16;11(1):5248. doi: 10.1038

Handley KF, Sims TT, Glassman D, Fleming ND, Lee S, Yao J, Yao H, Liu J, Bast Jr. RC, Zhao L, Zhang J, Bateman NW, Conrads KA, Hood BL, Barakat W, Westin SN, Celestino J, Rangel KM, Futreal A, Badal S, Pereira da Silva I, Eberlin LS, Conrads TP, Maxwell GL, Ram PT, Sood AK. If Looks Could Kill: Morphologic Subtypes of High-Grade Serous Ovarian Cancer. JAMA Netw Open. 2022 Oct 3;5(10):e2236626. doi: 10.1001/jamanetworkopen.2022.36626.

Mitchell D, Hunt AL, Conrads KA, Hood BL, Makohon-Moore SC, Rojas C, Maxwell GL, Bateman NW, Conrads TP. Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment. J Vis Exp. 2022 Jun 3;(184). doi: 10.3791/64171

Zhu Q, Wang J, Yu H, Hu Q, Bateman NW, Long M, Rosario S, Schultz E, Dalgard CL, Wilkerson MD, Sukumar G, Huang RY, Kaur J, Lele SB, Zsiros E, Villella J, Lugade A, Moysich K, Conrads TP, Maxwell GL, Odunsi K. Whole-Genome Sequencing Identifies PPARGC1A as a Putative Modifier of Cancer Risk in BRCA1/2 Mutation Carriers. Cancers (Basel). 2022 May 10;14(10):2350. doi: 10.3390/cancers14102350.

Bateman NW, Tarney CM, Abulez TS, Hood BL, Conrads KA, Zhou M, Soltis AR, Tend P, Jackson A, Tian C, Dalgard CL, Wilkerson MD, Kessler MD, Shriver CD, Hu H, Cote M, Parker GJ, Segars J, Al-Hendy A, Risinger JR, Darcy KM, Casablanca Y, Maxwell GL, Conrads TP, O’Connor TD. Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry. iScience, 2021 Dec 23;25(1):103665. doi: 10.1016/j.isci.2021.103665. eCollection 2022 Jan 21.