Sreya Mukherjee

Ph.D

Department of Primary Appointment:
School of Medicine
Surgery
Title
Research Assistant Professor of Surgery, SC2i Senior Bioinformatics Scientist
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Bioinformatics, Machine Learning pipelines, Wound healing, CDST's
Email
sreya.mukherjee.ctr@usuhs.edu
Office Phone
301-400-4335
Department Website
SURGICAL CRITICAL CARE INITIATIVE

Education

M.S. Bioinformatics, Johns Hopkins University, Baltimore, MD -(2020)
Ph.D. Computational Chemistry, University of South Florida, Tampa, FL-(2016)
M.S. Inorganic Chemistry, University of South Florida, Tampa, FL-(2011)
B.S. in Pharmacy, Birla Institute of Technology, INDIA-(2009)

Biography

Dr. Mukherjee's research interests lie at the intersection of bioinformatics and surgical critical care medicine, with a particular focus on understanding the molecular and regulatory underpinnings of wound healing and tissue regeneration. As a Senior Bioinformatics Scientist at the Surgical Critical Care Initiative (SC2i), her work is dedicated to developing the advanced analytical tools needed to combat critical illness and injury. She leverages her expertise in large-scale transcriptomic analysis, including differential expression and co-expression network analysis, to analyze complex 'omics' datasets. A key component of her work involves developing and deploying robust, reproducible bioinformatics pipelines on cloud computing platforms like Google Cloud for various processes. This approach allows for the large-scale interrogation of data to identify significant biological patterns and ultimately, to translate these insights into clinically meaningful tools. Her goal is to operationalize these data and machine learning-based findings into Clinical Decision Support Tools that can enhance the precision of surgical and critical care decisions within real-world workflows, thereby improving patient outcomes.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

SC2i Senior Bioinformatics Scientist

Representative Bibliography

• Mukherjee S, Brooks WH. Stromal Interaction Molecules as important therapeutic targets in diseases with dysregulated calcium flux. Biochim. Biophys. Acta (BBA)–Mol. Cell Res. 1843(10):2307–2314 (2014).

• Bhattacharya B, Mukherjee S. Cancer Therapy Using Antibiotics. J. Cancer Ther. 6(10):849–858 (2015).

• Le Dantec C, Gazeau P, Mukherjee S, Brooks WH, Renaudineau Y. How the environment influences epigenetics, DNA methylation, and autoimmune diseases. In: Epigenetics and Dermatology, pp. 467–485 (2015).

• Mukherjee S, Sparks R, Metcalf R, Brooks WH, Daniel K, Guida WC. Cupriphilic compounds to aid in proteasome inhibition. Bioorg. Med. Chem. Lett. 26(15):3826–3829 (2016). • Brooks WH, Mukherjee S. Stromal Interaction Molecule. In: Encyclopedia of Signaling Molecules, 2nd ed. (2017).

• Mukherjee S, Karolak A, Debant M, Buscaglia P, Renaudineau Y, Mignen O, Guida WC, Brooks WH. Molecular dynamics simulations of membrane-bound STIM1 to investigate conformational changes during activation upon calcium release. J. Chem. Inf. Model. 57(2):335–344 (2017).

• Hemon P, Renaudineau Y, Debant M, Goux NL, Mukherjee S, Brooks WH, Mignen O. Calcium signaling: From normal B cell development to tolerance breakdown and autoimmunity. Clin. Rev. Allergy Immunol. 53(2):141–165 (2017).

• Mukherjee S, Spriggs S, Wilder P, Varney K, MacKerell AD Jr, Weber DJ. Structure-based drug design of highly specific S100 inhibitors for targeting human cancers. Proc. AACR (2018).

• Burgos M, Mukherjee S, et al. The p.E152K-STIM1 mutation deregulates Ca²⁺ signaling contributing to chronic pancreatitis. J. Cell Sci. 134(3):jcs244012 (2021).

• Ursini G, Di Carlo P, Mukherjee S, et al. Prioritization of potential causative genes for schizophrenia in placenta. Nat. Commun. 14:2613 (2023).