Zygmunt Galdzicki Ph.D., M.Sc.

Education

University of Wroclaw, Department of Experimental Physics, Wroclaw, Poland. M.Sc.
Academy of Medicine, Wroclaw, Poland, Ph.D.
Laboratory of Neurosciences, NIA, NIH, Postdoctoral

Biography

1986-1988 Visiting Fellow, research in electrophysiology and teaching- lecturer graduate students Course on Cellular Biophysics and Physiology, Biophysics Laboratory, International School for Advanced Studies (SISSA), Trieste, Italy.
1987 Research Fellow, postdoctoral studies in electrophysiology under supervision of Dr. Franco Conti, Institute of Cybernetics and Biophysics, CNR, Genova- Camogli, Italy.
1990-1994 Visiting Associate, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.
1994-1999 Chief, Unit on Cell Pathophysiology, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.
2000-2004 Assistant Professor Department of Anatomy, Physiology and Genetics, USUHS, School of Medicine, Bethesda MD.
2004-2012 Associate Professor Department of Anatomy, Physiology and Genetics, USUHS, School of Medicine, Bethesda MD.
2012-present Professor, Department of Anatomy, Physiology and Genetics (Primary appointment), Neuroscience and Molecular and Cell Biology Program (Secondary appointments), USUHS, School of Medicine, Bethesda MD.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

L. Chakrabarti, T.K. Best, N.P. Cramer, R.S. Carney, J.T. Isaac, Z. Galdzicki, T.F. Haydar, Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci. 2010, 13(8):927-34.

J. Keck-Wherley, D. Grover, S. Bhattacharyya, X. Xu, D. Holman, E.D. Lombardini, R. Verma, R. Biswas, Z. Galdzicki, Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contribution to Down syndrome phenotypes, Developmental Neuroscience 2011, 33(5):451-67.

N. Cramer, Z Galdzicki From abnormal hippocampal synaptic plasticity in Down syndrome mouse models to cognitive disability in Down syndrome. Neural Plast. 2012:101542. doi: 10.1155/2012/101542.

JA Rusiecki, C Byrne, Z Galdzicki, V Srikantan, L Chen, M Poulin, L Yan, A Baccarelli PTSD and DNA methylation in select immune function gene promoter regions: a repeated measures case-control study of U.S. military service members, Front Psychiatry. 2013 Jun 24;4:56.

Representative Bibliography

Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N., Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination, Neuron. 2016 Mar 16;89(6):1208-22.

Logue OC, Cramer NP, Xu X, Perl DP, Galdzicki Z., Alterations of functional properties of hippocampal networks following repetitive closed-head injury. Exp Neurol. 2016 Mar;277:227-43.

Cramer NP, Xu X, F Haydar T, Galdzicki Z., Altered intrinsic and network properties of neocortical neurons in the Ts65Dn mouse model of Down syndrome. Physiol Rep. 2015 Dec;3(12).

Cramer NP, Xu X, Christensen C, Bierman A, Tankersley CG, Galdzicki Z., Strain variation in the adaptation of C57Bl6 and BALBc mice to chronic hypobaric hypoxia. Physiol Behav. 2015, 143:158-65.

C. Harashima, D.M. Jacobowitz, J. Witta, R.C. Borke, T.K. Best, R.J. Siarey, Z. Galdzicki, Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of DS, J of Comp.Neurobiology 2006 494(5):815-833.

R.J. Siarey, A. Kline-Burgess, M. Cho, A. Balbo, T.K. Best, C. Harashima, E. Klann, Z. Galdzicki Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down Syndrome, J Neurochem. 2006 98(4):1266-1277.

T.K. Best, R.J. Siarey, Z. Galdzicki Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB induced potassium current. J Neurophysiol. 2007 97: 892-900.

Olson LE, Roper RJ, Sengstaken CL, Peterson EA, Aquino V, Galdzicki Z, Siarey R, Pletnikov M, Moran TH, Reeves RH. Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Hum Mol Genet., 2007, 16: 774-782.

L. Chakrabarti, Z. Galdzicki, T.F. Haydar Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci. 2007 27:11483-11495.

K-H. Baek, A. Zaslavsky , R.C. Lynch, C. Britt, Y. Okada, R.J. Siarey, M.W. Lensch, I.H. Park, S.S. Yoon, T. Minami, J.R. Korenberg, R. Reeves, J. Folkman, W.C. Aird, Z. Galdzicki, S. Ryeom, Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009; 459:1126-30.