Zygmunt Galdzicki

Ph.D., M.Sc.

Department of Primary Appointment:
School of Medicine
Anatomy, Physiology and Genetics
Title
Professor of Anatomy, Physiology and Genetics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Neuroscience
Molecular and Cell Biology
Email
zgaldzicki@usuhs.edu
Office Phone
(301) 295-6587
Department Website
Anatomy, Physiology and Genetics

Education

University of Wroclaw, Department of Experimental Physics, Wroclaw, Poland. M.Sc.
Academy of Medicine, Wroclaw, Poland, Ph.D.
Laboratory of Neurosciences, NIA, NIH, Postdoctoral

Biography

1986-1989 Visiting Fellow, research in electrophysiology and teaching graduate students, Biophysics Laboratory, International School for Advanced Studies (SISSA), Trieste, Italy.
1987 Research Fellow, postdoctoral studies in electrophysiology under supervision of Dr. Franco Conti, Institute of Cybernetics and Biophysics, CNR, Genova- Camogli, Italy.
1990-1994 Visiting Associate, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.
1994-2000 Chief, Unit on Cell Pathophysiology, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.
2000-2004 Assistant Professor Department of Anatomy, Physiology and Genetics, USUHS, School of Medicine, Bethesda MD.
2004-2012 Associate Professor Department of Anatomy, Physiology and Genetics, USUHS, School of Medicine, Bethesda MD.
2012-present Professor, Department of Anatomy, Physiology and Genetics (Primary appointment), Neuroscience and Molecular and Cell Biology Program (Secondary appointments), USUHS, School of Medicine, Bethesda MD.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

L. Chakrabarti, T.K. Best, N.P. Cramer, R.S. Carney, J.T. Isaac, Z. Galdzicki, T.F. Haydar, Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci. 2010, 13(8):927-34.

J. Keck-Wherley, D. Grover, S. Bhattacharyya, X. Xu, D. Holman, E.D. Lombardini, R. Verma, R. Biswas, Z. Galdzicki, Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contribution to Down syndrome phenotypes, Developmental Neuroscience 2011, 33(5):451-67.

N. Cramer, Z Galdzicki From abnormal hippocampal synaptic plasticity in Down syndrome mouse models to cognitive disability in Down syndrome. Neural Plast. 2012:101542. doi: 10.1155/2012/101542.

JA Rusiecki, C Byrne, Z Galdzicki, V Srikantan, L Chen, M Poulin, L Yan, A Baccarelli PTSD and DNA methylation in select immune function gene promoter regions: a repeated measures case-control study of U.S. military service members, Front Psychiatry. 2013 Jun 24;4:56.

K-H. Baek, A. Zaslavsky , R.C. Lynch, C. Britt, Y. Okada, R.J. Siarey, M.W. Lensch, I.H. Park, S.S. Yoon, T. Minami, J.R. Korenberg, R. Reeves, J. Folkman, W.C. Aird, Z. Galdzicki, S. Ryeom, Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009; 459:1126-30.

Marion, C. M., K. L. Radomski, N. P. Cramer, Z. Galdzicki and R. C. Armstrong (2018). "Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery." J Neurosci 38(41): 8723-8736.

Representative Bibliography

Hatch, K., F. Lischka, M. Wang, X. Xu, C. D. Stimpson, T. Barvir, N. P. Cramer, D. P. Perl, G. Yu, C. A. Browne, D. L. Dickstein and Z. Galdzicki (2024). "The role of microglia in neuronal and cognitive function during high altitude acclimatization." Sci Rep 14(1): 18981.

Radomski, K. L., X. Zi, F. W. Lischka, M. D. Noble, Z. Galdzicki and R. C. Armstrong (2022). "Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury." Acta Neuropathol Commun 10(1): 67.

Cramer, N. P., A. Korotcov, A. Bosomtwi, X. Xu, D. R. Holman, K. Whiting, S. Jones, A. Hoy, B. J. Dardzinski and Z. Galdzicki (2019). "Neuronal and vascular deficits following chronic adaptation to high altitude." Experimental Neurology 311: 293-304.

Rusiecki, J., L. I. Levin, L. Wang, C. Byrne, J. Krishnamurthy, L. Chen, Z. Galdzicki and L. M. French (2020). "Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members." J Neuroinflammation 17(1): 20.

Sharma, R., N. P. Cramer, B. Perry, Z. Adahman, E. K. Murphy, X. Xu, B. J. Dardzinski, Z. Galdzicki, D. P. Perl, D. L. Dickstein and D. Iacono (2019). "Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes." Sci Rep 9(1): 16406.

Cramer NP, Xu X, Christensen C, Bierman A, Tankersley CG, Galdzicki Z., Strain variation in the adaptation of C57Bl6 and BALBc mice to chronic hypobaric hypoxia. Physiol Behav. 2015, 143:158-65.

Logue, O. C., N. P. Cramer, X. Xu, D. P. Perl and Z. Galdzicki (2016). "Alterations of functional properties of hippocampal networks following repetitive closed-head injury." Exp Neurol 277: 227-243.

R.J. Siarey, A. Kline-Burgess, M. Cho, A. Balbo, T.K. Best, C. Harashima, E. Klann, Z. Galdzicki Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down Syndrome, J Neurochem. 2006 98(4):1266-1277.

L. Chakrabarti, Z. Galdzicki, T.F. Haydar Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci. 2007 27:11483-11495.

C. Harashima, D.M. Jacobowitz, J. Witta, R.C. Borke, T.K. Best, R.J. Siarey, Z. Galdzicki, Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of DS, J of Comp.Neurobiology 2006 494(5):815-833.