Philip Jordan PhD, PGCertHE, Bbtech (Hns)

Education

Bachelor of Biotechnology (Hns) – Flinders University of South Australia, Australia (1997-2001)
Ph.D. in Cell and Molecular Biology - University of Edinburgh, Scotland (2002-2006)
Post-graduate Certificate in Higher Education - University of Sussex, England (2007-2009)
Post-doctoral training in Genome maintenance - University of Sussex, England (2007-2010)
Post-doctoral training in Reproductive Biology – The Jackson Laboratory, Maine, USA (2010-2013)

Biography

Philip Jordan received his undergraduate degree from Flinders University of South Australia and a Ph.D. from the University of Edinburgh, UK. He trained as a post-doctoral fellow (2007 to 2010) at the Genome Damage and Stability Centre, University of Sussex, UK, and the Jackson Laboratory, Maine, USA (2010 to 2013). In 2011, Dr. Jordan received a Pathway to Independence Award from the NIH. He was a principal investigator at Johns Hopkins University Bloomberg School of Public Health for ten years. In 2022, he became an Associate Professor in the Biochemistry and Molecular Biology Department at the Uniformed Services University of the Health Sciences in Maryland, USA.

Brief outline of work:
Our genomes must be maintained accurately from one generation to the next, and one cell division at a time. Otherwise, genome instability can result in aneuploidy, infertility, developmental defects, degenerative diseases, and cancer predisposition. Our research focuses on understanding the molecular mechanisms that monitor DNA replication accuracy and DNA damage repair proficiency, as well as processes that ensure accurate chromosome segregation and cell cycle progression. We use mouse and human pluripotent stem cells and mutant mouse models to elucidate key mechanisms required for detecting and combating challenges to genome integrity during gametogenesis and embryonic development.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Darwin Trust PhD scholarship from the University of Edinburgh, Scotland, 2002-2005.

UK Fulbright Distinguished Scholar Award from the US-UK Fulbright Commission, 2010.

K99-R00 Pathway to Independence Award from NICHD, NIH, 2012-2016

Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention, 2014-2015.

Discovery Award from Johns Hopkins University, 2015-2016.

American Society for Reproductive Medicine (ASRM) KY Cha Award, 2017-2018.

Catalyst Award from Johns Hopkins University, 2018-2019.

Discovery Award from Johns Hopkins University, 2022-2024.

Representative Bibliography

Stephen R. Wellard, Marnie W. Skinner, Xueqi Zhao, Chris Shults, Philip W. Jordan (2022) PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis. Molecular Biology of the Cell. 33(5):ar37

Stephen R. Wellard, Yujiao Zhang, Chris Shults, Xueqi Zhao, Matt McKay, Seve A. Murray, Philip W. Jordan (2021) Overlapping Roles for PLK1 and Aurora A kinases during Meiotic Centrosome Biogenesis in Mouse Spermatocytes. EMBO Rep. e51023

Florencia Pratto, Kevin Brick, Gang Cheng, Gabriel Lam, Jeffrey M. Cloutier, Daisy Dahiya, Stephen R. Wellard, Philip W. Jordan, R. Daniel Camerini-Otero (2021). Meiotic recombination mirrors patterns of germline replication in mice and humans. Cell. 184 (16), pp. 4251-4267.

Marina V. Pryzhkova, Michelle J. Xu and Philip W. Jordan (2020) Adaptation of the AID system for stem cell and transgenic mouse research. Stem Cell Research. (49): 102078

Marina V. Pryzhkova and Philip W. Jordan (2020) Adaptation of human testicular niche cells for pluripotent stem cell and testis development research. Tissue Engineering and Regenerative Medicine. (17), 223-235

Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina V. Pryzhkova, Philip W. Jordan (2020) SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. eLife. e61171.

Stephen R. Wellard, Karen Schindler and Philip W. Jordan (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. Journal of Cell Science. 133: jcs248831.

Tara Little and Philip W. Jordan (2020) PLK1 is required for normal chromosome compaction and microtubule organization in mouse oocytes. Molecular Biology of the Cell. (31), 1206–1217

Grace Hwang, Marilyn O’Brien, Fengyun Sun, John Eppig, Mary Ann Handel, Philip W. Jordan (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 144: 1648-1660.

Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Steve Murray and Philip W. Jordan (2014) Meiosis-specific cohesin component, Stag3 is essential for mediating recombination and synapsis between homologous chromosomes and maintaining sister chromatid cohesion. PLoS Genetics; 10 (7) e1004413