Angela R. Melton-Celsa


Department of Primary Appointment:
School of Medicine
Microbiology and Immunology
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Toxins, Diagnostics, and Therapies
Basic Biology of Bacterial, Viral, or Parasite Diseases
Office Phone


BS, Loyola Marymount University
Ph.D. Virginia Commonwealth University, Medical College of Virginia

Representative Bibliography

Russo LM, Melton-Celsa AR, O'Brien AD. Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a. J Infect Dis. 2016 Apr 15;213(8):1271-9.

Melton-Celsa AR, O'Brien AD, Feng PC. Virulence Potential of Activatable Shiga Toxin 2d-Producing Escherichia coli Isolates from Fresh Produce. J Food Prot. 2015 Nov;78(11):2085-8.

Melton-Celsa AR, O'Brien AD. New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli. Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.EHEC-0013-2013.

Boisen N, Melton-Celsa AR, Scheutz F, O'Brien AD, Nataro JP. Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combination. Gut Microbes. 2015 Jul 4;6(4):272-8.

Melton-Celsa AR, Carvalho HM, Thuning-Roberson C, O'Brien AD. Protective efficacy and pharmacokinetics of human/mouse chimeric anti-Stx1 and anti-Stx2 antibodies in mice. Clin Vaccine Immunol. 2015 Apr;22(4):448-55.

Melton-Celsa AR. Shiga Toxin (Stx) Classification, Structure, and Function. Microbiol Spectr. 2014 Aug;2(4):EHEC-0024-2013.

Zangari T, Melton-Celsa AR, Panda A, Smith MA, Tatarov I, De Tolla L, O'Brien AD. Enhanced virulence of the Escherichia coli O157:H7 spinach-associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin. Infect Immun. 2014 Dec;82(12):4968-77.

Boisen N, Hansen AM, Melton-Celsa AR, Zangari T, Mortensen NP, Kaper JB, O'Brien AD, Nataro JP. The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer. J Infect Dis. 2014 Dec 15;210(12):1909-19.

Russo LM, Melton-Celsa AR, Smith MA, Smith MJ, O'Brien AD. Oral intoxication of mice with Shiga toxin type 2a (Stx2a) and protection by anti-Stx2a monoclonal antibody 11E10. Infect Immun. 2014 Mar;82(3):1213-21.

Zumbrun SD, Melton-Celsa AR, O'Brien AD. When a healthy diet turns deadly. Gut Microbes. 2014 Jan-Feb;5(1):40-3.