Ann E. Jerse


Department of Primary Appointment:
School of Medicine
Microbiology and Immunology
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Adaptation of Neisseria gonorrhoeae to the female reproductive tract; animal modeling of gonococcal and gonococcal-chlamydial infections; antibiotic resistance and microbial fitness; development of novel anti-infectives and vaccines
Office Phone


B.A. Medical Technology, Indiana State University (1979)
Ph.D. Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA (1983)
Post-doctoral Fellow, University of North Carolina, Chapel Hill, NC (1991-1993)

Representative publications, projects, and/or deployments

Jerse AE, Wu H, Packiam M, Vonck RA, Begum AA, and LE Garvin. 2011. Estradiol-treated female mice as surrogate hosts for Neisseria gonorrhoeae genital tract infections. Front. Microbio. 2:107. doi: 10.3389.

Vonck R.A., T. Darville, C.M. O’Connell, and A.E. Jerse. 2011. Chlamydial infection increases gonococcal colonization in a novel murine coinfection model. Infect Immun. 79:1566-1577. PMCID: PMC3067530.

Muench D.F., Kuch D.J., Wu H., Begum A.A., Veit S.J., Pelletier M. E., Soler-Garcia A.A., and A.E. Jerse. 2009. H2O2-producing lactobacilli inhibit gonococci in vitro but not during experimental genital tract infection. J. Infect. Dis. 199:1369–1378. PMCID: PMC2864085.

Song W., Condron S., Mocca B.T., Veit S.J., Hill D., Abbas A., and A.E. Jerse. 2008. Local and humoral responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17-β-estradiol-treated mice. Vaccine 26:5741-5751. PMCID: PMC 2855896.

Packiam R., H. Wu, S.J. Veit, N. Mavrogiorgios, A.E. Jerse*, and R.R. Ingalls. 2012. Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice. Mucosal Immunol. 5:19-29. *Co-senior author with RR Ingalls.

Simms, A.N., and A.E. Jerse. 2006. In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human CEACAM receptors Infect. Immun. 74:2965-2974. PMCID: PMC1459723.

Warner D.J., W.M. Shafer, and A.E. Jerse. 2008. Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol. Micro. 70:462-478. PMCID: PMC 2602950.

Kunz A.N., A.A. Begum, H. Wu, J.A. D’Ambrozio, J.M. Robinson, W.M. Shafer, M.C. Bash, and A.E. Jerse. 2012. Impact of fluoroquinolone resistance mutations on gonococcal fitness and in vivo selection for compensatory mutations. J Infect Dis 205:1821-1829.

Packiam M., Y. Yedery, A.A. Begum, R.W. Carlson, J. Ganguly, G.D. Sempowski, M.S. Ventevogel, W.M. Shafer, and A.E. Jerse. 2014. Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection. Infect. Immun. 82:2170-2179.

Hobbs M.M., J.E. Anderson, J.T. Balthazar, J.L. Kandler, R.W. Carlson, J. Ganguly, A.A. Begum, J.A. Duncan, J.T. Lin, P.F. Sparling, A.E. Jerse, and W.M. Shafer. 2013. Lipid A structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men. mBio 4:e00892-13.