Guisen Jiang M.D.

Education

1961 1967 The School of Basic Medical Sciences, Beijing Medical University (Now: Peking University Health Science Center); Beijing, China
1978 1981 Graduate study in Department of Biophysics, Beijing Medical University. (Now: Peking University Health Science Center); Beijing, China
1982 1983 National NMR Professional Training Program Sponsored by The Ministry of Education of China.

Biography

Education:
1961 1967 M.D. (Equivalent) The School of Basic Medical Sciences, Beijing Medical University (Now: Peking University Health Science Center); Beijing, China
1978 1981 M.S. (Biophysics) Graduate study in Department of Biophysics, Beijing Medical University (Now: Peking University Health Science Center); Beijing, China
Postgraduate Training:
1982 1983 National NMR Professional Training Program Sponsored by The Ministry of Education of China
1985 1986 Research Associate in Dr. C. S. Johnson's Lab. of the Dept of Chemistry and Dr. D. A. Gabriel's Lab. of the Medical School in the University of North Carolina at
Chapel Hill, U. S. A. Studied protein molecular diffusion coefficient by Laser Holographic Relaxation Spectroscopy and cell electrophoresis by Laser Doppler Light
Scattering.
1986 1988 Research Associate in Dr. Valerie W. Hu’s Lab, Dept. of Biochemistry, USUHS, Bethesda, Maryland. U.S.A. Studied the interaction of toxin (diphtheria) protein
with membrane.
1988 1988 Postdoctor in Dr. M. D. Rollag's Lab and Dr. M. R. Adelman's Lab. of the Dept. of Anatomy and Cell Biology, USUHS. Set up the microinjection apparatus and
studied the pigment movement of cultured amphibian melanophores by microinjection method.
1988 1991 Research Associate in Dr. K. V. Holmes' Lab. Dept. of Pathology, USUHS.
Identification and characterization of the receptor for Mouse Hepatitis Virus (MHV; a murine Coronavirus) as a member of the Carcinoembryonic antigen Family of
glycoproteins.
1991- 1992 Research Associate in Dr. R. M. Friedman's Lab. Dept. of Pathology, USUHS.
Studied tumor suppressor gene (rrg: ras recession gene), the gene product (lysyl oxidase) and its role in reversion process of cell transformation.
Professional Experience:
1968 1978 Physician of Occupational Diseases and Doctor of Radiation Department. Hospital of First Coal Mining Engineering Company of Gan su Province, China.
1981 1985 Lecturer of Biophysics, Dept. of Biophysics. One of the originators of the Central laboratory with Mass spectrometer, NMR, Electron microscopes and other large
equipment in Beijing Medical University, China.
1992- 1995 Senior Research Associate in Dept. of R. & D. Univax Biologics Inc.Purification and characterization of recombinant protein and polysaccharide for vaccine
development. Developed the assay methods (Enzyme assay, uronic acid assay, O-acetylation assay, nonionic detergent assay.)
1995 1995 Research scientist in Dr. M. D. Rollag's Lab. of the Dept. of Anatomy, Physiology and Genetics, USUHS. Identifying and characterization of an opsin (melanopsin) in t
he cultured amphibian melanophores.
1995- 2003 Research Assistant professor in Dept. of Anatomy, physiology and Genetics, USUHS. Cloning and expression of Melanopsin gene of amphibian, chicken, mouse and
human.
2003- 2017 Research Assistant professor in Dept. of Anatomy, physiology and Genetics, USUHS. Proteomic research focusing on the mass spectrometry (MS) running High
performance liquid chromatography (HPLC)–MS. Techniques’ development and maintenance of MS.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

1968 1978 Physician of Occupational Diseases and Doctor of Radiation Department. Hospital of First Coal Mining Engineering Company of Gan su Province, China.

1981 1985 Lecturer of Biophysics, Dept. of Biophysics. One of the originators of the Central laboratory with Mass spectrometer, NMR, Electron microscopes and other large equipment in Beijing Medical University, China

1992- 1995 Senior Research Associate in Dept. of R. & D. Univax Biologics Inc. Purification and characterization of recombinant protein and polysaccharide for vaccine development. Developed the assay methods (Enzyme assay, uronic acid assay, O-acetylation assay, nonionic detergent assay.)

1995- 2003 Research Assistant professor in Dept. of Anatomy, physiology and Genetics, USUHS. Cloning and expression of Melanopsin gene of amphibian, chicken, mouse and human.

2003- 2017 Research Assistant professor in Dept. of Anatomy, physiology and Genetics, USUHS. Proteomic research focusing on the mass spectrometry (MS) running High performance liquid chromatography (HPLC)–MS. Techniques’ development and maintenance of MS.

Guisen Jiang: Shield Ruler and Methods of Using the Same. U.S. Patent Application Number 61/902,893 on 11/12/2013 at the United States Patent and Trademark Office.

Representative Bibliography

Jiang Gui sen and Lin Ke chun: Fluidity Changes of Membrane Lipid Regions in Leukemic Lymphocytes. Acta Biochimica et Biophysica Sinica, Vol. 16, No. 6, P. 521-527, 1984 (with English Summary)

K. C. Lin and G. S. Jiang: 31P NMR Study of the Interaction Between Surfactants and Liposomes. Acta Biophysica Sinica, Vol. 2, No. 3, P. 233, 1986. (with English Summary)

Jiang Gui sen and Valerie W. Hu: Characterization of Diphtheria Toxin mediated Marker Release from Asolectin Vesicles. Biophysical Journal, Vol. 53, No. 2, part 2, P. 314a. 1988.

Gui sen Jiang, Rikki Solow, and Valerie W. Hu: Characterization of Diphtheria Toxin Induced Lesion in Liposomal Membranes: An Evaluation of the Relationship Between Toxin Insertion and "Channel" Formation. J. Biol. Chem., Vol. 264, No. 23, P. 13424, 1989.

Guisen Jiang, Rikki Solow, and Valerie W. Hu: Fragment A of Diphtheria Toxin Causes pH-Dependent Lesions in Model Membranes. J. Biol. Chem., Vol.264, No. 29, P. 17170, 1989.

Richard K. Williams, Guisen Jiang, Stuart W. Snyder, Mark F. Frana and Kathryn V. Holmes: Purification of the 110K Glycoprotein Receptor for Mouse Hepatitis Virus ( MHV )-A59 from Mouse Liver and Identification of a Nonfunctional, Homologous Protein in MHV-Resistant SJL/J Mice. J. Virol., Vol. 64, No. 8, P. 3817-3823, 1990.

Richard K. Williams, Guisen Jiang, and Kathryn V. Holmes: Receptor for mouse hepatitis Virus is a member of the Carcinoembryonic antigen Family of glycoproteins. Proc. Natl. Acad. Sci. USA. Vol. 88, p. 5533-5536, 1991.

Ignacio Provencio, Guisen Jiang, Willem J. De Grip, William Par Hayes, and Mark D. Rollag: Melanopsin: An opsin in melanophores, brain, and eye Proc. Natl. Acad. Sci. USA. Vol. 95, p. 340-345, 1998

Ignacio Provencio, Ignacio R. Rodriguez, Guisen Jiang, William Par Hayes, Ernesto F. Moreira, and Mark D. Rollag: A Novel Human Opsin in the Inner Retina The Journal of Neuroscience, January 15, 2000, 20(2):600–605

Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC. PP2A Dephosphorylates Elf-1 And Determines The Expression Of CD3zeta And FcRgamma In Human Systemic Lupus Erythematosus T Cells. J Immunol. 2008 Sep 1;181(5):3658-64