Harvey B Pollard
EducationINSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
Rice University, Houston, TX B.A. 1964 Biology
University of Chicago, Chicago, IL M.D. 1969 Medicine
University of Chicago, Chicago, IL Ph.D. 1973 Biochemistry
BiographyDr. Pollard received his undergraduate degree from Rice University, and his MD and PhD (in Biochemistry) degrees from the University of Chicago. Following postdoctoral training at the NIH and at Oxford University, Dr. Pollard returned to the NIH in the U.S. Public Health Service (USPHS), eventually becoming intramural Chief of the Laboratory of Pathology, and then Chief of the Laboratory of Cell Biology and Genetics, NIDDK. Dr. Pollard subsequently moved across Wisconsin Avenue to become Chair of the Department of Anatomy, Physiology and Genetics, in the Uniformed Services University School of Medicine, Bethesda, MD. Dr. Pollard’s principal hypothesis-driven research focus has been on proinflammatory mechanisms. Dr. Pollard is the Founding Director of the Collaborative Health Initiative Research Program (CHIRP), a whole genome sequencing (WGS) program of investigation, jointly sponsored by NHLBI and the Department of Defense. In addition, Dr. Pollard is also Founding Director of The American Genome Center (TAGC), a Department of Defense entity that is one of only four academic Genome Centers in the United States.The goals of CHIRP and the TAGC are to develop “precision medicine” as an aid to diagnosis and treatment of disorders of common interest in both civilian and military disease cohorts. Dr. Pollard has received the NIH Inventor’s Award, and has authored nearly 350 peer reviewed scientific publications and numerous invited chapters.
Representative publications, projects, and/or deployments
M.D. University of Chicago School of Medicine,
Ph.D. (Biochemistry) Department of Biochemistry, University of Chicago School of Medicine,
Research Associate, Laboratory of Chemical Biology, NIAMDD, National Institutes of Health
Post Doctoral Trainee, Laboratory of Molecular Biophysics, Oxford University
Senior Investigator Reproduction Research Branch, NICHD,
Senior Investigator, Clinical Hematology Branch, NIADDK,
Laboratory Chief, Laboratory of Cell Biology and Genetics,NIADDK,
Professor and Chair of the Department of Anatomy and Cell Biology, USUSOM, USUHS
Professor and Chair of the Department of Anatomy, Physiology & Genetics, USUSOM, USUHS
Director of the Collaborative Health Initiative Research Program (CHIRP) and The American Genome Center (TAGC)
Dalgard C, Eidelman O, Jozwik C, Olsen CH, Srivastava M, Biswas R, e EudyY,.Rothwell SW, Mueller GP, Yuan P, Drevets WC, Manji HK, Vythlingam M, Charney DS. Neumeister A, Ursano RJ, Jacobowitz DM, Pollard HB, and Bonne O., The MCP-4/MCP-1 Ratio in Plasma is a Candidate Circadian Biomarker for Chronic Post-Traumatic Stress Disorder. Translational Psychiatry, 7(2):e1025 doi:10.1038/tp2016.285, 2017, 2016.
Dalgard CL, Polston KF, Sukumar G, Mallon CT, Wilkerson MD, Pollard HB. MicroRNA Expression Profiling of the Armed Forces Health Surveillance Branch Cohort for Identification of "Enviro-miRs" Associated With Deployment-Based Environmental Exposure. J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S97-S103. doi: 10.1097/ JOM.0000000000000764., 2016
. Pollard HB, Shivakumar C, Starr J, Eidelman O, Jacobowitz DM, Dalgard CL, Srivastava M, Wilkerson MD, Stein MB, Ursano RJ. "Soldier's Heart": A Genetic Basis for Elevated Cardiovascular Disease Risk Associated with Post-traumatic Stress Disorder. Front Mol Neurosci. 2016 Sep 23;9:87, 2016
Wang H, Cebutaru L, Yang QF, Jozwik C, Pollard BS, Pollard HB and Guggino WB. CFTR controls the activity of the NFκB by enhancing the degradation of TRADD. Cell Physiol.Biochem. , 40(5): 1063-1078, 2016. 2016.
. Singh VK, Newman VL, Romaine PL, Hauer-Jensen M, Pollard HB. Use of biomarkers for assessing radiation injury and efficacy of countermeasures.
. Mears D, Pollard HB. Network science and the human brain: Using graph theory to understand the brain and one of its hubs, the amygdala, in health and disease.
Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935.PMID: 26823392
. Caohuy H, Yang Q, Eudy Y, Ha TA, Xu AE, Glover M, Frizzell RA, Jozwik C, Pollard HB. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR). J Biol Chem. 2014 Dec 26;289(52):35953-35968. doi: 10.1074/jbc.M114.598649. Epub 2014 Nov 10.
. Kumar P, Bhattacharuyya S, Peters KW, Glover ML, Sen A, Cox RT, Bhattacharyya A, Kundu S, Caohuy H, Frizzell RA, Pollard HB and Biswas R. Functional rescue of [ΔF508]CFTR in native cystic fibrosis cells by miR-16. Gene Ther. 22(11): 908-916, 2015
Dalgard CL, Jacobowitz DM, Singh V, Saleem KS, Ursano RJ, Starr JM, and Pollard HB. A novel analytical brain block tool to enable functional annotation of discriminatory transcript biomarkers among discrete regions of the fronto-limbic circuit in primate brain.. Brain Research 1600:42-58, 2015.