Jacob Hogue M.D.

Education

University of California, San Francisco (2008 - 2011)
Medical Genetics Residency/Fellowship

Madigan Army Medical Center (2005 - 2008)
Pediatrics Residency

Uniformed Services University of the Health Sciences (2001 - 2005)
M.D.

Valparaiso University (1997 - 2001)
B.S. in Chemistry and Biology

Biography

COL Hogue is currently the Chief of the Department of Clinical Investigation (DCI), the Chief of Genetics, the Chair of the Bioethics Board, and the Chair of the Performance Improvement Committee at Madigan Army Medical Center. As the Chief of DCI he is responsible for research and scholarly activity at Madigan to include the maintenance of laboratory facilities, hiring and supervision of research personnel, facilitation of external funding, and the provision of research education and training resources. His personal research interests include the etiology, characterization, and management of multiple congenital anomaly syndromes, autism, intellectual disability, and the genetics of disorders with particular military relevance. As the only Medical Geneticist serving the military on the West Coast, he is clinically responsible for the medical care of individuals of all ages with suspected or confirmed genetic conditions throughout the region.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Chief, Department of Clinical Investigation, Madigan Army Medical Center (2023-Present)

Chief, Genetics, Madigan Army Medical Center (2015-Present)

Chair, Performance Improvement Committee, Madigan Army Medical Center (2023-Present)

Chair, DoD Precision Care Advisory Panel, Genomics Policy Sub-Committee (2022-Present)

Chair, Bioethics Board, Madigan Army Medical Center (2021-Present)

DoD Representative, Secretary of Health and Human Services Advisory Committee on Heritable Disorders in Infants and Children (2019-Present)

Chair, Madigan Army Medical Center Institutional Review Board (2016-2022)

Associate Program Director, Madigan Army Medical Center Pediatrics Residency (2015-2021)

Operation Border Security, 547th Area Support Medical Company (2018)

Operation Enduring Freedom, 10th Sustainment Brigade (2012)

Representative Bibliography

Krick JA, Hogue JS, Studer MA, Reese TR, Weiss EM. “Battlefield triage and resource allocation during a pandemic: what can we learn from the past and how must we adapt for the future?” The Medical Journal (Fort Sam Houston Texas) 2022 July-Sep:38-42

McTiernan N, Tranebjaerg L, Bjorheim AS, Hogue JS, Wilson WG, Schmidt B, Boerrigter MM, Nybo ML, Smeland MF, Turner Z, Arnesen T. “Biochemical analysis of novel NAA10 variants suggest distinct pathogenic mechanisms involving impaired protein N-terminal acetylation.” Human Genetics 2022;141:1355-1369.

Chooey J, Trexler C, Becker AM, Hogue JS. “Esophageal atresia/tracheoesophageal fistula and proximal symphalangism in a patient with a NOG nonsense mutation.” American Journal of Medical Genetics Part A 2022;188:269-271

Krick JA, Hogue JS, Reese TR, Studer MA. “Uncertainty: an uncomfortable companion to decision-making for infants.” Pediatrics 2020;146(Suppl 1): S13-S17.

Garren B, Stephan M, Hogue JS. “NRAS associated RASopathy and embryonal rhabdomyosarcoma.” American Journal of Medical Genetics Part A 2020;182:195-200.

Kruszka P, Berger SI, Casa V, Dekker MR, Gaesser J, Weiss K, Martinez AF, Murdock DR, Louie RJ, Prijoles EJ, Lichty AW, Brouwer OF, Zonneveld-Huijssoon E, Stephan MJ, Hogue J, Hu P, Tanima-Nagai M, Everson JL, Prasad C, Cereda A, Iascone M, Schreiber A, Zurcher V, Corsten-Janssen N, Escobar L, Clegg NJ, Delgado MR, Hajirnis O, Balasubramanian M, Kayserili H, Deardorff M, Poot RA, Wendt KS, Lipinski RJ, Muenke M. “Cohesin complex-associated holoprosencephaly.” Brain 2019;142:2631-2643.

Stevens CA*, Hogue JS*, Hopkins RJ, Lombardo RC, Vergano SAS. “Congenital lumbar hernia- a feature of diabetic embryopathy?” American Journal of Medical Genetics Part A 2018;176:2243- 2249. (*contributed equally to this study)

Schacht JP, Farnworth E, Hogue J, Rohena L. “Tetraploid-diploid mosaicism in a patient with pigmentary anomalies of hair and skin: a new dermatologic feature.” Clinical Case Reports 2017;6:103-108.

Dimitri P, De Franco E, Habeb AM, Gurguz F, Moussa K, Taha D, Wales JK, Hogue J, Slavotinek A, Shetty A, Balasubramanian M. “An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 (GLIS3).” American Journal of Medical Genetics Part A 2016; 170: 1918-1923.

Dimitri P, Habeb AM, Garbuz F, Millward A, Wallis S, Moussa K, Akcay T, Taha D, Hogue J, Slavotinek A, Wales JK, Shetty A, Hawkes D, Hattersley AT, Ellard S, De Franco E. “Expanding the clinical spectrum associated with GLIS3 mutations.” Journal of Clinical Endocrinology and Metabolism 2015; 100: E1362-1369.