Jason Lees


Department of Primary Appointment:
School of Medicine
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Determining new targets for therapy of autoimmune disease
T cell biology and trafficking
Office Phone


1999 B.S. Biology (with Honors), University of South Dakota, Vermillion, SD
2004 Ph.D. Immunology, University of Iowa, Iowa City, IA


Dr. Lees started his career by training in T cell biology and cellular cancer immunotherapy. During his subsequent postdoctoral fellowship at he focused on the interactions between T cells and host tissue during autoimmune reactions, particularly focusing on autoimmune neuroinflammation. He then moved on to further investigations of autoimmune inflammation with studies on type I diabetes and a continued focus on neuroinflammation which remains active within the lab.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

W.M. Keck Postdoctoral Program in Molecular Medicine at Washington University Fellowship: W.M. Keck Postdoctoral Program in Molecular Medicine Washington University School of Medicine

National Multiple Sclerosis Society Fellowship

Representative Bibliography

Clark AA, Nurmukhambetova S, Li X, Munger SD, Lees JR#. Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction. Journal of Leukocyte Biology, 2016 Oct;100(4):699-70

Li X, Lees JR. Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development. Immunology, 2013 Mar;138(3):208-15.

Lees JR, Golumbek PT, Sim J, Russell JH. Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. Journal of Experimental Medicine 2008 Oct 27; 205(11):2633-42