Jessica D. Rosarda

PhD

Department of Primary Appointment:
School of Medicine
Anatomy, Physiology and Genetics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Cellular stress, signal transduction, chemical biology, molecular medicine
Neuroscience (NES), Molecular and Cell Biology (MCB)
Email
jessica.rosarda@usuhs.edu
Office Phone
301-295-2055
Department Website
Department of Anatomy, Physiology, and Genetics

Education

PhD. in Chemical and Biological Sciences, The Scripps Research Institute 2023
MSc. in Pharmacy, University of Florida 2013
Bsc. in Biology, Washington and Lee University 2010

Biography

Cellular stress contributes to the pathogenesis of numerous etiologically diverse diseases. Cells respond to stress by activating signaling pathways that function to neutralize the stressor or promote adaptation. However, persistent or hyper- activation of these pathways can also lead to cellular dysfunction and apoptosis. As either an insufficient or an overactive stress response can cause widespread cell death and tissue damage, both pharmacologic activators and inhibitors of these pathways have been proposed as therapeutic interventions using a one-drug, many-disease paradigm. At USU, my laboratory will work to define stress pathway signaling dynamics in military-relevant disorders, determine the metabolic factors that govern these stress responses, and identify novel approaches for resolving toxic stress and/or stress signaling involved in both acute and chronic conditions.

Representative Bibliography

Biosketch Link
Jessica's NCBI Bibliography

Madrazo N, Khattar Z, Powers ET, Rosarda JD*, Wiseman RL*. Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations. Mol Biol Cell. 2024 Mar 27

Rosarda JD, Giles S, Harkins-Perry S, Mills EA, Friedlander M, Wiseman RL, Eade KT. Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity. Nat Commun 2023.

Rosarda JD, Stanton CR, Chen EB, Bollong MJ, Wiseman RL, Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation. Isr J Chem 2023.

Perea V, Baron KR, Dolina V, Aviles G, Kim G, Rosarda JD, Guo X, Kampmann M, Wiseman RL. Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells. Cell Chem Biol 2023.

Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol 2021.

Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR 3rd, Wilson AA, Connors LH, Kotton DN, Wiseman RL, Murphy GJ. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports 2020.

Glembotski CC, Rosarda JD, Wiseman RL. Proteostasis and Beyond: ATF6 in Ischemic Disease. Trends Mol Med 2019.

Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid 2018.