Joseph J. Mattapallil
B.V.Sc., M.S., Ph.D., PMP®
Education1997: Ph.D., Immunology, University of California Davis, Davis, CA
1994: M.S., Animal Science, University of California Davis, Davis, CA
1986: B.V.Sc, Veterinary Medicine, College of Veterinary Medicine, APAU, India
2017: PMP®, Certified Project Management Professional, Program Management Institute, USA
Biography2020 - present: Professor, Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University
2013 - 2020: Associate Professor, Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University
2007 - 2012: Assistant Professor, Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University
Representative publications, projects, and/or deployments
Dean's Fellow, F. E. Hébert School of Medicine, Uniformed Services University School of Medicine (2021)
Module Co-Director, Bench to Bedside and Beyond (MSIII) Module (2016 - present); Director, Graduate Molecular Virology (2008 - present)
"F. E. Hébert School of Medicine Dean's Annual Faculty Teaching Award", Uniformed Services University School of Medicine (2019)
"F. E. Hébert School of Medicine Dean's Faculty Impact Award", Uniformed Services University School of Medicine (2017, 2018)
Certified Program Management Professional (PMP®), Project Management Institute (2017 – present)
Member, DAIT, NIAID Radiation-Nuclear Countermeasures Program Data and Safety Monitoring Committee (RNMC-DSMB), 2011 – 2014, 2018 – 2022
Standing/Chartered Member of AIP (2014 – 2018) and HIVD (2018 – 2020) Study Sections, Center for Scientific Review, NIH
Member of over 25 NIH Special Emphasis Review (R01, R21, P01, F31/32) Panels (2006 – present)
Academic Editor, Plos One (2013 - present), Journal of Clinical Medicine (2018 - present), Microorganisms (2017 - present); Associate Editor, Journal of Immunology (2013 - 2018), Cellular Immunology (2015 - present); Review Editor, Frontiers in Microbiology (2018 - present)
Ad Hoc Reviewer for Science Advances, Journal of Clinical Investigation, Scientific Reports, Journal of Infectious Diseases, Mucosal Immunology, Plos Pathogens, FASEB Journal, Blood, Retrovirology, Journal of Virology
Blum, F. C., Hardy, B. L., Bishop-Lilly, K, A., Frey, K. G., Hamilton, T., Whitney, J. B., Lewis, M. G., Merrell, D. S., and Mattapallil, J. 2020. Microbial dysbiosis during Simian immunodeficiency virus infection is partially reverted with combination anti-retroviral therapy. Scientific Reports: 10(1):6387.
George, J., Johnson, R. C., Mattapallil, M. J., Renn, L., Rabin, R., Merrell, D. S and Mattapallil, J. J. 2019. Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection. PLoS One. 14(9):e0221159
Valiant, W. G., Mattapallil, M. J., Higgs, S., Huang, Y. S., Vanlandingham, D. L., Lewis, M. G and Mattapallil, J. 2019. Simultaneous coinfection of macaques with zika and dengue viruses does not enhance acute viremia but leads to activation of monocyte subsets and biphasic release of pro-inflammatory cytokines. Scientific Reports: 9: 7877 (1-11).
Valiant, W. G., Huang, Y., Vanlandingham, D. L., Higgs, S., Lewis, M. G., and Mattapallil, J. 2018. Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after Dengue infection. Emerging Microbes and Infections. 7: 130 (1-11).
Valiant, W.G., Lalani, T., Yun, H., Kunz, A., Burgess, T. H., and Mattapallil, J. 2018. Human serum with high neutralizing antibody titres against both Zika and Dengue virus shows delayed in vitro antibody dependent enhancement of Dengue virus infection. Open Forum Infectious Diseases. 5: ofy151 (1-4).
George, J., Valiant, W., Mattapallil, M., Walker, M., Huang, Y., Vanlandingham, D. L., Misamore, J., Greenhouse, J., Weiss, D. E., Verthelyi, D., Higgs, S., Andersen, H., Lewis, M. G., and Mattapallil, J. 2017. Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques. Scientific Reports. 7: 10498 (1-10).
Eberly, M. D., Kader, M., Hassan, W., Rogers, K. A., Zhou, J., Mueller, Y.M., Mattapallil, M. J., Piatak, M., Lifson, J. D., Katsikis, P. D., Roederer, M., Villinger, F and Mattapallil, J.J. 2009. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to SIV during acute infection. J. Immunology. 182: 1439-48.
Kader, M., Wang, X., Piatak, M., Lifson, J., Roederer, M., Veazy, R and Mattapallil, J. J. 2009. a4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection. Mucosal Immunology: 2: 439-49.
Mattapallil, J., Douek, D.C., Buckler-White, A., Montefiori, D., Letvin, N. L., Nabel, G. J and Roederer, M. 2006. Vaccination prevents the destruction of CD4 memory T cells during acute SIV infection. J. Exp. Med. 203: 1533-41.
Mattapallil, J., Douek, D. C., Hill, B., Nishimura, Y., Martin, M. A and Roederer, M. 2005. Massive infection and loss of memory CD4 T-cells in multiple tissues during acute SIV Infection. Nature. 434: 1093-97.