Maria X. Leighton


Department of Primary Appointment:
School of Medicine
Anatomy, Physiology and Genetics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Medical Education
The Biology and Genetics of Cancer
Office Phone


Doctor of Medicine and General Surgery, University of Chile. Santiago Chile, 1994
Licentiate in Medicine, University of Chile. Santiago Chile 1992


Leighton X, Eidelman O, Jozwik C, Pollard HB, Srivastava M. ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities. Methods Mol Biol. 2017; 1513:23-35.

Srivastava A, Leighton X, Eidelman O, Starr J, Jozwik C, Srivastava M, Pollard H.B. and Singh VK. Personalized radioproteomics: Identification of a protein biomarker signature for preemptive rescue by tocopherol succinate in CD34+ irradiated progenitor cells isolated from a healthy control donor. Journal of Proteomics & Bioinformatics. 8:2, 23-30,

Diverse Effects of ANXA7 and p53 on LNCap Prostate Cancer Cells Are associated with Regulation of SGK1 Transcription and Phosphorylation of the SGK1 Target FOXO3A. Meera Srivastava, Ximena Leighton, Joshua Star Ofer #Eidelman, and Harvey Pollard. BioMed Research International, Volume 2014, (2014).

Mears D, Zimliki CL, Atwater I, Rojas E, Glassman M, Leighton X, Pollard HB, Srivastava The Anx7 (+/-) Knockout Mutation Alters Electrical and Secretory Responses to Ca- Mobilizing Agents in Pancreatic β-cells. Cell Physiol. Biochem.2012; 29 (5-6): 697-704.

Torosyan Y, Dobi A, Glasman M, Mezhevaya K, Naga S, Huang W, Paweletz C, Leighton X, Pollard HB, Srivastava M. Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells. Oncogene 2010; 29 (17). 2457-66

Torosyan Y, Simakova O, Naga S, Mezhevaya K, Leighton X, Diaz J, Huang W, Pollard H, Srivastava M. Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells. Int J Cancer 2009; 125(11):2528-39.

Leighton, X., Srikantan, V., Sukumar, S., Pollard, H.B. and Srivastava, M. Significant allelic loss of ANX7 region (10q21) in hormone receptor negative breast carcinomas, 2004.Cancer Letts 210 (2004) 239-244.

Srivastava, M., Glasman, M., Leighton, X., Miller, G., Montagna, C., Reid, T., and Pollard, H.B.Genomic instability and gene expression profile in cancer prone Anx7 (+/-) knockout mouse and cell line models. Proc Natl Acad Sci USA. 2003; 100, 14287-14292.

Srivastava, M., Montagna, C., Leighton, X., Glasman, M., Naga, S., Eidelman, O., Reid, T. and Pollard, H.B., Haploinsufficiency of ANX 7 tumor suppressor gene and consequent genomic instability promotes tumorgenesis in the ANX7 (+/-) mouse.Proc. Natl. Acad. Sci. 2003, 100, 14287-14292.