Michael D. Rouse


Department of Primary Appointment:
School of Medicine
Research Assistant Professor, SC2i Lead Scientist
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Predictive and diagnostic biomarkers, assay and model development,
Immunology, trauma and wound care
Office Phone


2012 PhD University of South Carolina, Columbia, SC
2005 M.S. University of Virginia, Charlottesville, VA
2003 B.S. University of Maryland Baltimore County, Baltimore, MD


Dr. Rouse, Research Assistant Professor in the Department of Surgery, joined USU in August 2021. Dr. Rouse has spent over 20 years in the areas of drug discovery, preclinical pipeline development, product advancement, host immunology, immunotherapy, bacteria-host interactions, and wound healing and care. Throughout his career, he has been awarded over $14M collectively in research funding to help address a broad range of technical and knowledge gaps within the biomedical field.

Dr. Rouse routinely leads and manages interdisciplinary and cross-functional teams across a broad range of scientific areas, such as microbiology, immunology, biomaterial engineering, biophysics, and computational biology, to promote product development and maximize clinical outcomes requiring complex medical decision making. In addition to his appointment as a USUHS Research Assistant Professor under the Department of Surgery, Dr. Rouse currently works as the Lead Scientist for Surgical Critical Care Initiative (SC2i) and the Walter Reed National Military Medical Center (WRNMMC). His laboratory routinely collaborates and uses multi-omics (proteins, transcripts, genomics) approaches to manage and facilitate the development of biomarker-driven Clinical Decision Support Tools (CDSTs), such as advanced analytics, machine learning, and precision medicine diagnostics. Dr. Rouse is primarily focused on identifying biomarkers and developing new assays to better understand the translational mechanisms and improve clinical outcomes of combat-related injuries and conditions.

Representative publications, projects, and/or deployments

SC2i Lead Scientist (August 2021 - Present)

Senior Scientist at Naval Medical Research Center (August 2016 - July 2021)


Bergmann-Leitner, E., Bobrov, A.G., Bolton, J.S., Rouse, M.D., Heyburn, L., Pavlovic, R., Garry, B.I., Alamneh, Y., Long, J., Swierczewski, B., Tyner, S., Getnet, D., Sajja, V.J., Antonic, V. 2022. Blast Waves Cause Immune System Dysfunction and Transient Bone Marrow Failure in a Mouse Model. Frontiers Bioengineering. 10:821169.

Rouse, M., Stanbro, J. Roman, J.A., Lipinski, M., Jacobs, A., Biswas, B., Regeimbal, J., Henry, M., Stockelman, M.G., Simons, M.P. 2020. Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model. Frontiers in Microbiol. 11:414.

Jacobs, A., Dugan, J., Duplessis, C., Rouse, M., Deshotel, M., Simons, M., Biswas, B., Nikolich, M., Stockelman, M., Tyner, S., Demons, S., Watters, C. 2018. “Practical Applications of Bacteriophage Therapy: Biofilms to Bedside. “ In "Antibacterial Drug Discovery to combat MDR - Natural Compounds, Nanotechnology and Novel Synthetic Sources.” (I. Ahmad, and K. Rumbaugh, editors). Springer, New York, NY. Antibacterial Drug Discovery to Combat MDR.