Mingqiang Ren Ph.D.

Education

BS. Anhui Agricultural University, Hefei, Anhui, China
MS. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China
PhD. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China

Biography

Mingqiang Ren received his Ph.D. degree in physiology and biochemistry from China and completed his postdoctoral training at the Research Institute for Animal Biology in Germany and the Johns Hopkins University Cancer Center. He is currently a Research Assistant Professor in the Department of Military and Emergency Medicine (MEM) at the Uniformed Services University. Previously, he was a research scientist at Roswell Park Cancer Institute in Buffalo, NY, and an assistant professor in the Department of Biochemistry and Molecular Biology at the Medical College of Georgia.

Dr. Ren has many years of experience and expertise in genomics, bioinformatics, and mouse models. He is a translational scientist and his research has mainly focused on blood diseases, including blood cancer and sickle cell disease. His current research mainly focuses on gene-environment interactions and their impact on human diseases/traits using biobank datasets.

Representative Bibliography

1. Ren M*, Sambuughin N, Mungunshukh O, Edgeworth D, Hupalo D, Zhang X, Wilkerson M, Dalgard CL, O’Connor FG, Deuster PA. Genome-Wide Analysis of Exertional Rhabdomyolysis in Sickle Cell Trait Positive African Americans. Genes (Basel). 2024 Mar 26;15(4):408. doi: 10.3390/genes15040408.

2. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher AE. IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. Sci Immunol. 2020 Sep 18;5(51):eabb5590.

3. Ren M, Kazman JB, Abraham PA, Atias-Varon D, Heled Y, Deuster PA. Gene expression profiling of humans under exertional heat stress: Comparisons between persons with and without exertional heat stroke. J Therm Biol 2019, 85:102423.

4. Hu T, Wu Q, Chong Y, Qin H, Poole CJ, van Riggelen J, Ren M*, Cowell JK. FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome. Leukemia. 2018; 32(11):2363-2373

5. Cowell JK, Qin H, Hu T, Wu Q, Bhole A, Ren M*. Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas. Int J Cancer. 2017, 141(9):1822-1829

6. Cowell JK, Qin H, Chang C-S, Kitamura, E. and Ren M*. A model of BCR-FGFR1 driven human AML in immunocompromised mice. British Journal of Haematology, 2016, 175(3):542-545.

7. Qin H, Sami Malek, Cowell JK, and Ren M*. Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromized mouse model. Oncogene, 2016, 27;35(43):5686-5691.

8. Qin H, Wu Q, Cowell JK, and Ren M*. FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model. Haematologica, 2016, 101(3).

9. Ren M*, Qin H, Ren R, Cowell JK. Ponatinib suppresses the development ofmyeloid and lymphoid malignancies associated with FGFR1 abnormalities. Leukemia. 27(1):32-40, 2013.

10. Ren M*, Qin H, Kitamura E, Cowell JK. Disregulation of multiple signaling pathways in the development of myeloid and lymphoid malignancies associated with the CNTRL-FGFR1 fusion kinase in human and mouse models. Blood; 122(6):1007-16, 2013.