T John Wu


Department of Primary Appointment:
School of Medicine
Gynecologic Surgery and Obstetrics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Neuroendocrine Regulation of Stress
Bioactive Neuropeptide Metabolism
Office Phone


Bachelor of Science (December 1985)
Major: Zoology
University of Texas at Austin

Doctor of Philosophy (May 1991)
Field of Study: Physiology of Reproduction
Texas A&M University
College Station, TX

Postdoctoral Fellow (1991 - 1994)
Field of Study: Neuroendocrinology
Columbia University
New York, NY

Postdoctoral Fellow (1994 - 1999)
Field of Study: Molecular Neuroendocrinology
Mount Sinai School of Medicine
New York, NY

Representative Bibliography

Buban KN, SE Saperstein, M Oyola, SW Rothwell, TJ Wu (2023) Alterations in corticotropin releasing factor contribute to hypothalamic-pituitary-adrenal axis dysregulation following a single or multiple days of sleep restriction. Neuroscience Letters (accepted)

Miller A, RM Daniels, JA Sheng, TJ Wu, RJ Handa (2022) Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex. Journal of Neuroendocrinology 34:e13212

Miller L, MBL Careaga, RJ Handa, TJ Wu (2022) The effects of chronic variable stress in combination with photoperiod alteration on the hypothalamic-pituitary-adrenal axis response and behavior of male and female mice. Neuroscience 496:105-118

Cho-Clark, MJ, G Sukumar, NM Vidal, C Olsen, S Raiciulescu, L Mariño-Ramírez, CL Dalgard, TJ Wu (2021) Comparative transcriptome analysis between patient and primary tumor-derived endometrial cancer cell lines to determine signaling pathways and markers linked to cancer progression. Oncotarget 12:2500-2513

Ludovic LD, S Simmons, M Oyola, S Gouty, TJ Wu and FS Nugent (2022) Blast-induced mild traumatic brain injury alterations of corticotropin-releasing factor neuronal activity in the mouse hypothalamic paraventricular nucleus. Frontiers in Synaptic Neuroscience 27

Mohr, MA, AM Wong, G Sukumar, CL Dalgard, TJ Wu, YE Wu, PE Micevych (2021) RNA-sequencing of two hypothalamic nodes reveals vastly different temporal and transcriptomic responses to estradiol in the female rat. Plos ONE 16(8):e0256148

Russell AL, L Miller, J Yi, R Keil, RJ Handa, TJ Wu (2021) Knockout of the circadian gene, PER2, disrupts diurnal CORT secretion and increases anxiety- and depressive-like behaviors. BMC Neuroscience 22(1):5

Oyola, MG, RC Johnson, BM Bauman, AL Russell, KG Frey, M Clark, KN Buban, K Bishop-Lilly, RJ Handa, DS Merrell, TJ Wu (2020) Metabolism and Gut Microbiome Alteration Following Photoperiod and Dietary Isoflavone Interaction. Endocrinology, Diabetes & Metabolism 4(1):e00190

Buban KN, EA Shupe, S Rothwell, TJ Wu (2020) Sex differences in the hypothalamic-pituitary-adrenal axis response following a single or multiple days of sleep restriction. Stress 10:1-10

Russell, AL, R Richardson, B Bauman, I Hernandez, S Saperstein, RJ Handa, TJ Wu (2018) Differential responses of the HPA axis to mild blast traumatic brain injury in males and females. Endocrinology 159:2363-2375