Thomas P. Flagg


Department of Primary Appointment:
School of Medicine
Anatomy, Physiology and Genetics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Ion Channel Structure & Function
Co-Module Director, Foundation in Medicine Module
Office Phone


B.S. Stevens Institute of Technology, Hoboken, NJ Major: Chemical Biology; Minor: History 1989 – 1993
M.S. University of Maryland, Baltimore, MD Major: Physiology 1994 – 1996
Ph.D. University of Maryland, Baltimore, MD Major: Physiology 1996 – 2001
Mentor: Paul A. Welling, M.D.
Postdoctoral Washington University School of Medicine, St. Louis, MO 2001 - 2004
Mentor: Colin G. Nichols, Ph.D.


Geiger RM, MG Klein, N Fatima, RE Goldstein, MJ Krantz, MC Haigney, and TP Flagg. Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes. JACC Clin Electrophysiol, in press, 2020.

Khayrullina G, Moritz KE, Schooley JF, Fatima N, Viollet C, McCormack NM, Smyth JT, Doughty ML, Dalgard CL, Flagg TP, Burnett BG. SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs. Skelet Muscle.10:16, 2020.

Krantz MJ, Flagg TP, Haigney MCP. Dangerous Needle Stick. Circulation. 141:1424-1426, 2020.

Goldstein RE, Klein MG, Ouimet SP, Shou M, Hood MN, Flagg TP, Haigney MC. Hemodynamic Effects of Late Sodium Current Inhibitors in a Swine Model of Heart Failure. J Card Fail. 25:828-836, 2019.

Flagg, TP, SW Rothwell, and BE Neubauer. Avoiding the chopping block in curricular reform - re-imagining physiology laboratories in the era of integrated medical curricula. Adv Physiol Educ, 41: 279-285, 2017.

Klein, MG, M Shou, J Stohlman, M Haigney, RR Tidwell, TP Flagg, RE Goldstein, MC Haigney. Role of IK1 Suppression on Terminal Action Potential Repolarization in the Failing Heart. Heart Rhythm, 14:1217-1223, 2017.

Klein, MG, MC Haigney, PS Mehler, N Fatima, TP Flagg, and MJ Krantz. Potent Inhibition of hERG Channels by the Over-The Counter Anti-Diarrheal Agent Loperamide, JACC Clin Electrophysiol, 251, 2016.

Fatima, N, DC Cohen, JF Schooley, Jr., MC Haigney, WC Claycomb, CL Dalgard, RT Cox, SE Bates, and TP Flagg. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol. Frontiers Pharmacol, 6:168, 2015.

Schooley, Jr., JF, AMA Namboodiri, RT Cox, R Bunger, and TP Flagg. Acetate Transiently Inhibits Myocardial Contraction by Increasing Mitochondrial Calcium Uptake. BMC Physiol,14:12, 2014.

Fatima, N., JF Schooley, Jr., WC Claycomb, and TP Flagg. Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PlosOne, 7: e41533, 2012.