Trimble L. B. Spitzer


Colonel, Air Force

Department of Primary Appointment:
School of Medicine
Gynecologic Surgery and Obstetrics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Infertility, Environmental & Occupational Exposures/Reproduction
Endometrial Diseases


Fellowship: REI Fellowship, University of California, San Francisco, CA
Residency: OBGYN Residency, George Washington University, Washington, DC
Medical School: Eastern Virginia Medical School, Norfolk, VA
Undergraduate: B.S. in Physics (cum laude), Mary Baldwin University, Staunton, VA


Dr. Trimble Spitzer attended Mary Baldwin University, graduating cum laude in 1999 with a Bachelor of Science degree in Physics. She studied medicine at Eastern Virginia Medical School, Norfolk, VA, graduating with her medical degree in 2005. She completed internship and residency training in Obstetrics and Gynecology at George Washington University in Washington, D.C. and subspecialty fellowship training at the University of California, San Francisco (UCSF).
During fellowship, Dr. Spitzer was involved in laboratory research in the field of endometrial implantation receptivity, as it relates to identification, isolation and characterization of the transcriptome and signaling pathways of endometrial mesenchymal stem cells. Dr. Spitzer’s contribution filled an existing gap in literature on the subject of endometrial mesenchymal progenitor cells and their characteristics.
After the completion of fellowship training in 2012, Dr. Spitzer joined the medical staff at the Naval Medical Center, Portsmouth (NMCP) Virginia, and Langley Air Force Base, VA, where she continues to practice Reproductive Endocrinology/Infertility and Obstetrics and Gynecology. She completed her ABOG General OBGYN Board certification in 2012 and Subspecialty certification in Reproductive Endocrinology and Infertility in 2014. She served as the Program Director for the Residency in Gynecologic Surgery and Obstetrics at NMCP for 3 years. Dr. Spitzer is currently a Module Director for the Pre-Clerkship module, Reproduction and Endocrinology at the Uniformed Services University of Health Sciences (USUHS). As Associate Professor within the Department of Gynecologic Surgery and Obstetrics, she has earned faculty development certificates in both Teaching and Academic Leadership. Dr. Spitzer received the ASRM/ NICHD/ DUKE Clinical Research/ Reproductive Scientist Training (CREST) Scholar award for her academic research work in the field of reproductive medicine. She continues to be active in research and publish in areas of infertility and women’s health.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

OBGYN Residency Program Director Naval Medical Center Portsmouth 72 Residents over 3 years

Pre-Clerkship Module Director, Reproduction & Endocrinology Uniformed Services University of the Health Sciences (USUHS)

American Board of Obstetrics and Gynecology - National Specialty Board examiner

ASRM/ NICHD/ DUKE Clinical Research/ Reproductive Scientist Training (CREST) scholar award

American Congress of Obstetricians and Gynecologists- Fellow

American Society for Reproductive Medicine- Fellow

Representative Bibliography

Kim JW, Grounds BE, Van Bokkem KC, Raiciulescu S, Spitzer TL. Impact of Oral Ovulatory Induction Medications Among Female Military Members and Military Beneficiaries. Mil Med. 2022 Oct 19:usac307. doi: 10.1093/milmed/usac307. Epub ahead of print. PMID: 36260066.

George AF, McGregor M, Gingrich D, Neidleman J, Marquez RS, Young KC, Thanigaivelan KL, Greene WC, Tien PC, Deitchman AN, Spitzer TL, Roan NR. Female Genital Fibroblasts Diminish the In Vitro Efficacy of PrEP against HIV. Viruses. 2022 Aug 4;14(8):1723. doi: 10.3390/v14081723. PMID: 36016345.

Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Diamond MP, Krawetz SA, Sun F, Zhang H, Santoro N, Steiner AZ. Biomarkers of Stress and Male Fertility. Reprod Sci. 2022 Apr;29(4):1262-1270. doi: 10.1007/s43032-022-00853-x. Epub 2022 Feb 1. PMID: 35106743; PMCID: PMC9078052.

DeYoung TH, Stortz SK, Riffenburgh RH, Wren GM, Spitzer TL, Lutgendorf MA, Thagard AS. Establishing the Most Accurate Due Date in Dichorionic Twin Gestations by First and Second Trimester Ultrasound. J Ultrasound Med. 2021 Nov;40(11):2319-2327. doi: 10.1002/jum.15615. Epub 2021 Jan 11. PMID: 33426717.

Ma T, Luo X, George AF, Mukherjee G, Sen N, Spitzer TL, Giudice LC, Greene WC, Roan NR. HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread. Elife. 2020;9:e55487. Published 2020 May 26. PMID: 32452381.

George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, Chen JC, Herzig E, Laustsen A, Marques de Menezes EG, Houshdaran S, Pilcher CD, Norris PJ, Jakobsen MR, Greene WC, Giudice LC, Roan NR.. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on IL-11 signaling. Human Repro. 2020 Mar 27;35(3):617-640. PMID: 32219408.

Mayer KH, Spitzer TLB. Offspring gender rates in active duty fighter pilots and flight officers. Reprod Toxicol. 2019 Aug;87:8-10. PMID: 31059773.

Smart VA, Roger EI, Ricca RL, Spitzer TL, Fox JA. Fibroepithelial Vaginal Polyps in a Newborn Female. Urology. 2019 Jun 27. pii: S0090-4295(19)30597-7. PMID: 31255540.

Barragan F, Irwin JC, Balayan S, Erikson DW, Chen JC, Houshdaran S, Piltonen TT, Spitzer TL, George A, Rabban JT, Nezhat C, Giudice LC. Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis. Biol Reprod. 2016 May;94(5):118. PMID: 27075616.

T.T. Piltonen, J.C. Chen, M. Khatun, M. Kangasniemi, A. Liakka, T. Spitzer, N. Tran, H. Huddleston, J.C. Irwin, L.C. Giudice. Endometrial stromal fibroblasts (eSF) from women with PCOS have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. Hum Repro. 2015 May;30(5):1203-15. PMID: 25750105.