Yuanyi Feng


Department of Primary Appointment:
School of Medicine
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Cerebral cortical neurogenesis
Genome stability and cell differentiation; neuroprogenitor vascular interaction
Office Phone


MD: Peking University Health Science Center, Beijing, P.R. China
PhD: Johns Hopkins University, Baltimore, Maryland
Postdoc Training: Harvard Medical School, Boston, Massachusetts

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

2017 - Associate Professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine

2006 - 2017 Assistant Professor, Department of Neurology, Northwestern University Feinberg School of Medicine

2002 - 2006 Instructor, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School

Current grant support: R01, NIH/NINDS, Functions of filamin in brain development and diseases (2015 - 2020)

Representative Bibliography

Lanctot, A.A., Guo, Y., Le Y., Edens, B.M., Nowakowski, R.S., and Feng, Y. 2017. Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 20(5): 1148-60

Houlihan, S.L.*, Lanctot, A.A.*, Guo, Y. and Feng, Y. 2016. Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. eLife,5: e17823. *These authors contributed equally

Houlihan, S.L. & Feng, Y. 2014. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. eLife 3: e03297.

Lanctot, A.A., Peng, C., Pawlisz, A.S., Joksimovic, M., and Feng, Y. 2013. Spatially-dependent Dynamic MAPK Modulation by the Nde1-Lis1-Brap Complex Patterns Mammalian CNS. Dev. Cell 25: 241-55 *featured article; F1000 recommend article

Pawlisz, A.S. and Feng, Y. 2011. Three-dimensional Regulation of Radial Glial Functions by Lis1-Nde1 and Dystrophin Glycoprotein Complexes. PLoS Biol. 9(10):e1001172

Alkuraya, F.S*, Cai, X*., Emery, C., Mochida, G. H., Al DosariM. S., FelieJ. M., Hill, R.S., Barry, B.J., Partlow, J.N., Gascon, G. G., Kentab, A., Jan, M., Shaheen, R., Feng, Y., †, and Walsh, C.A† 2011. NDE1 is mutated in extreme microcephaly, and is required for cell cycle progression through phosphorylation on its C-terminus. Am J Hum Genet. 88: 536-47 *These authors contributed equally; † Co-corresponding author

Pawlisz, A.S., Mutch, C., Wynshaw-Boris, A., Chenn, A., Walsh, C.A. and Feng, Y. 2008. LIS1-Nde1 Dependent Neuronal Fate Control Determines Cerebral Cortical Size and Lamination. Hum Mol Genet. 17: 2441-55

Feng, Y., Chen, M.H., Moskowitz, I., Mendonza,A.M., Vidali, L., Nakanura, F., Kwiatkowski, D.J., and Walsh, C.A. 2006. Filamin A is Required for Cell-Cell Contact in Vascular Development and Cardiac Morphogenesis. Proc Natl Acad Sci. 103: 19836-41

Feng, Y. and Walsh, C.A. 2004. Mitotic Spindle Regulation by Nde1 (mNudE) Controls Cerebral Cortical Size. Neuron, 44: 279-93 * Featured article; F1000 recommended article

Feng, Y., Olson, E.C., Stukenberg, P.T., Flanagan, L.A., Kirschner, M.W. and Walsh, C.A. 2000. Interactions Between LIS1 and mNudE, a Central Component of the Centrosome, are Required for CNS Lamination. Neuron 28: 665-679; * Featured article