Alexandru Korotcov PhD

Education

Postdoctoral Fellow (Molecular Imaging, MRI/MRS, Optical Imaging of live cells and animals, Nanotechology in Medicine) - Howard University, Department of Radiology, Molecular Imaging Laboratory, Washington, DC (2006-2008)
Postdoctoral Fellow (Naniotechnology) - National Taiwan University of Science and Technology, Taipei, Taiwan (2004-2006)
DSc (Physics and Mathematics) - State University of Moldova, Chisinau, Moldova (2003)
MSc (Physics) - State University of Moldova, Chisinau, Moldova (1996)

Biography

Dr. Korotcov is an experimental and computational medical physicist with expertise in nanotechnology, biomedical imaging methods, neuroradiology, cancer research, traumatic brain injury research (TBI), targeted imaging probes, and drug development research. He also has extensive experience in medical image acquisition and processing, machine learning methods, and applications in life science and computational sciences domains.

During his more than two decades of research experience, he has participated in and coordinated diverse research projects, collaborating with researchers from the National Institute of Health, Georgetown University, Johns Hopkins University, University of California Los Angeles, Washington University at St. Louis, Children’s National Medical Center, and Human Genome.

Currently, Dr. Korotcov is working as a Senior MRI scientist and advisor at the Biomedical Research Imaging Core at the Uniformed Services University of the Health Sciences for research in the field of translational imaging research focusing on advanced MRI. In addition to his advising role, he is intensively involved in developing data processing and analysis pipelines for medical diagnostic imaging.

Dr. Korotcov's work has led to more than 50 scientific and abstract presentations nationally and globally. Moreover, he has published more than 20 papers in the fields of physics and material sciences and has more than 20 publications in the biomedical field.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Assistant Professor (2021 - present) - Department of Radiology & Radiological Sciences, Uniformed Services University, Bethesda, MD

Senior MRI Scientist and Advisor (2012 - present), Biomedical Research Imaging Core, Department of Radiology & Radiological Sciences, HJF/USUHS, Bethesda, MD

Assistant Professor (2009 - 2012) - Department of Radiology, Howard University, Washington, DC

Imaging Scientist (2009 - 20212) - Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC

Member of International Society for Magnetic Resonance in Medicine (2017 - present)

Member of World Molecular Imaging Society (2006 - 2013)

Certificate of Appreciation from TriService Nursing Research Program at USUHS for contribution to military nursing (2017)

World Molecular Imaging Congress 2011 Poster Session walk-through highlights (2011)

3rd Place in Abstract Competition – Postdoctoral Fellow category, Howard University College of Medicine, Research Day 2010 (2010)

Certificate of Merit, The Radiological Society of North America Annual Meeting - RSNA 2009, USA (2009)

Representative Bibliography

Alexandru V. Korotcov, Yunpeng Ye, Yue Chen, Fayun Zhang, Sophia Huang, Stephen Lin, Rajagopalan Sridhar, Samuel Achilefu, Paul C. Wang. Glucosamine Linked Near-infrared Fluorescent Probes for Imaging of Solid Tumor Xenograft. Molecular Imaging and Biology, 2012; 14(4):443-51.

Heier CR, Guerron AD, Korotcov A, Lin S, Gordish-Dressman H, Fricke S, Sze RW, Hoffman EP, Wang P, Nagaraju K. Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits. PLoS One, 2014; 9(11):e112477, PMCID: PMC4229202

Stinnett GR, Lin S, Korotcov AV, Korotcova L, Morton PD, Ramachandra SD, Pham A, Kumar S, Agematsu K, Zurakowski D, Wang PC, Jonas RA, Ishibashi N. Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model. J Am Heart Assoc. 2017 Aug 15;6(8), PMCID: PMC5586442

Korotcov A, Tkachenko V, Russo DP, Ekins S. Comparison of Deep Learning With Multiple Machine Learning Methods and Metrics Using Diverse Drug Discovery Data Sets. Mol Pharm. 2017 Dec 4;14(12):4462-4475. doi: 10.1021/acs.molpharmaceut.7b00578. Epub 2017 Nov 13. PMID: 29096442

Cramer NP, Korotcov A, Bosomtwi A, Xu X, Holman DR, Whiting K, Jones S, Hoy A, Dardzinski BJ, Galdzicki Z. Neuronal and vascular deficits following chronic adaptation to high altitude. Exp Neurol. 2019 Jan;311:293-304бб PMID: 30321497

Donald V Bradshaw, Andrew K Knutsen, Alexandru Korotcov, Genevieve M Sullivan, Kryslaine L Radomski, Bernard J Dardzinski, Xiaomei Zi, Dennis P McDaniel, Regina C Armstrong. Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological and functional measures. Acta Neuropathol Commun. 2021 May;9:89, PMCID: PMC8130449, DOI: 10.1186/s40478-021-01193-8

Hutchinson EB, Romero-Lozano A, Johnson HR, Knutsen AK, Bosomtwi A, Korotcov A, Shunmugavel A, King SG, Schwerin SC, Juliano SL, Dardzinski BJ, Pierpaoli C. Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury. Front Neurosci. 2022 Feb 23;15:779533. doi: 10.3389/fnins.2021.779533. PMID: 35280340

McNamara EH, Knutsen A, Korotcov A, Bosomtwi A, Liu J, Fu AH, Kostelnik C, Grillakis A, Spencer H, Dardzinski BJ, McCabe JT. Meningeal and visual pathway MRI analysis after single and repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-induced disruption in male and female mice. J Neurotrauma. 2022 Jun;39(11-12):784-799. doi: 10.1089/neu.2021.0494. PMID: 35243900

Puthillathu Narayanan, Moffett John R., Korotcov Alexandru, Bosomtwi Asamoah, Vengilote Ranjini, Krishnan Jishnu K. S., Johnson Erik A., Arun Peethambaran, Namboodiri Aryan M. Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology. Fronti in Pharmacology 2023 Dec, Vol 14. doi: 10.3389/fphar.2023.1293280